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TranscriptomicsmicroRNA expression in human hepatitis c virus (HCV) liver biopsy samples
In order to infer the inverse expression relationships between microRNAs and mRNAs during HCV infection, we profiled both microRNA and mRNA expressions in HCV positive (HCV+) and HCV negative (HCV-) human liver biopsy tissue samples. This series includes all microRNA profiles. This series includes m...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-15288 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of host response to mouse-adapted SARS virus in wild type, STAT1 -/-, and IFNAR1 -/- mouse genetic backgrounds
The mechanisms by which pulmonary lesions and fibrosis are generated during SARS-CoV infection are not known. Using high-throughput mRNA profiling, we examined the transcriptional response of wild-type (WT), type I interferon receptor knockout (IFNAR1−/−), and STAT1 knockout (STAT1−/−) mice infected...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-36016 | biostudies-arrayexpress
TranscriptomicsA single N66S mutation in the PB1-F2 protein of influenza A virus increases virulence by inhibiting the early interferon response in vivo
This study used virological, histological, and global gene expression from an experimental murine model of influenza infection to study the contribution of a specific mutation in the PB1-F2 protein (PB1-F2 N66S) of influenza A to viral pathogenesis. 6-8 week old, wild-type, female, C57Bl/6 mice were...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-35940 | biostudies-arrayexpress
TranscriptomicsmicroRNA and mRNA expression in human hepatitis C Virus liver biopsies
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series This dataset is part of the TransQST collection.
ORGANISM(S): Homo sapiens 
2010-03-08 | E-GEOD-15387 | biostudies-arrayexpress
TranscriptomicsAcute host transcriptonal response to A/Texas/36/91 influenza and A/Texas/36/91 influenza containing the NS1 gene from r1918 in A549 cells
The M-bM-^@M-^\Spanish influenzaM-bM-^@M-^] of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transc...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-37829 | biostudies-arrayexpress
ProteomicsAge-induced methylmalonic acid accumulation promotes cancer aggressiveness and metastatic disease
TMT protein abundance profiling of human serum from 30 young and 30 older adults.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-02-18 | MSV000084974 | MassIVE
TranscriptomicsAcute host transcriptonal response to r1918 influenza and r1918 influenza containing the NS1 gene from A/Texas/36/91 in A549 cells
The “Spanish influenza” of 1918 claimed an unprecedented number of lives, yet the determinants of virulence for this virus are still not fully understood. Here, we used functional genomics and an in vitro human lung epithelial cell infection model to define the global host transcriptional response t...
ORGANISM(S): Homo sapiens 
2012-05-13 | E-GEOD-37951 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression in response to SARS mouse adapted variants MA-15, MA-15epsilon, and MA-15-gamma in young and aged mice
Purpose of this experiment was to study the host-transcriptional response to MA-15, MA-15epsilon, and MA-15-gamma in both young and aged mice to further understand the differences between response within each age group, and the age-related differences in response to each virus. Young (8 weeks old) a...
ORGANISM(S): Mus musculus 
2014-06-02 | E-GEOD-36969 | biostudies-arrayexpress
TranscriptomicsEarly and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus.
This study revealed important similarities but also critical differences between the H5N1 and 1918-reassortant viruses, highlighting aspects of the host–pathogen interface caused by highly virulent influenza viruses. Animals assigned to 4 experimental groups (n = 8) matched for age, weight, and sex,...
ORGANISM(S): Macaca fascicularis 
2011-11-01 | E-GEOD-33351 | biostudies-arrayexpress
UnknownCharacterizing Long COVID Symptoms During Early Childhood.
Not available
S-EPMC12117493 | biostudies-literature
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