Sort   by:  
 Page size 
MetabolomicsEffects of rosiglitazone treatment on lipid composition
Not available
ORGANISM(S): Homo sapiens 
ST000675 | MetabolomicsWorkbench
TranscriptomicsDevelopmental and extracellular matrix-remodeling processes in rosiglitazone-exposed neonatal rat cardiomyocytes_TS
The objective of this study was to investigate the effects of rosiglitazone (Avandia) on gene expression in neonatal rat ventricular myocytes. Myocytes were exposed to rosiglitazone ex vivo. The two factors examined in the experiment were drug exposure (r
ORGANISM(S): Rattus norvegicus 
2015-02-21 | E-MTAB-2426 | biostudies-arrayexpress
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA, Rosiglitazone, and a combination of both
This SuperSeries is composed of the following subset Series: GSE36716: Muscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA or Rosiglitazone in Dietary-Obese Mice GSE36717: Muscle Involvement in Preservation of Metabolic Flexibility by a Combination Treatment using...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36718 | biostudies-arrayexpress
TranscriptomicsA systems biology approach to understand the pathophysiological mechanisms of cardiac pathological hypertrophy associated with rosiglitazone
Cardiac pathological hypertrophy is associated with a significantly increased risk of coronary heart disease and has been observed in diabetic patients treated with rosiglitazone, whereas most published studies do not suggest a similar increase in risk of cardiovascular events in pioglitazone-treate...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-48977 | biostudies-arrayexpress
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by Treatment using n-3 PUFA or Rosiglitazone in Dietary-Obese Mice
Impaired resistance to insulin, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. The hampered metabolic adaptability triggers a further damage of insulin signaling. Since skeletal muscle is the mai...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36716 | biostudies-arrayexpress
TranscriptomicsRosiglitazone-induced molecular changes in adipose progenitors
White adipose tissue regulates metabolism; the importance of this control is highlighted by the ongoing pandemic of obesity and associated complications such as diabetes, atherosclerosis, and cancer. White adipose tissue maintenance is a dynamic process, very little is known about how pharmacologic ...
ORGANISM(S): Mus musculus 
2012-01-18 | E-GEOD-30116 | biostudies-arrayexpress
TranscriptomicsTranscriptome Alteration in the Diabetic Heart by Rosiglitazone: Implications for Cardiovascular Mortality
The type 2 diabetes medication, rosiglitazone, has come under scrutiny for possibly increasing the risk of cardiac disease and death. To investigate the effects of rosiglitazone on the diabetic heart, we performed cardiac transcriptional profiling of a murine model of type 2 diabetes, the C57BL/KLS...
ORGANISM(S): Mus musculus 
2012-03-28 | E-GEOD-36875 | biostudies-arrayexpress
TranscriptomicsGW7647 and Rosiglitazone treated human differentiated adipocytes
Objective : This work aimed at characterizing PPARα involvement in metabolism regulation and at comparing PPARα and PPARγ roles in human white adipocytes. Research Design and Methods : Profiling of gene expression alterations was assessed with microarrays and RT-qPCR. Primary cultures of human adipo...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-15862 | biostudies-arrayexpress
TranscriptomicsMuscle Involvement in Preservation of Metabolic Flexibility by a Combination Treatment using n-3 PUFA and Rosiglitazone in Dietary-Obese Mice
Impaired resistance to insulin, the key defect in type 2 diabetes (T2D), is associated with a low capacity to adapt fuel oxidation to fuel availability, i.e., metabolic inflexibility. The hampered metabolic adaptability triggers a further damage of insulin signaling. Since skeletal muscle is the mai...
ORGANISM(S): Mus musculus 
2012-09-07 | E-GEOD-36717 | biostudies-arrayexpress
TranscriptomicsExpression data from rosiglitazone treated, rosiglitazone withdrawal and untreated control Zucker Diabetic Fatty rats.
Insulin resistance and islet failure are the two etiological roots of type 2 diabetes mellitus, and understanding global islet gene expression may provide insight into the mechanisms that regulate islet function. In this study we systematically investigated the gene expression profile and proliferat...
ORGANISM(S): Rattus norvegicus 
2013-06-21 | E-GEOD-30147 | biostudies-arrayexpress
Sort   by:  
 Page size