Sort   by:  
 Page size 
GenomicsA highly sensitive and robust method for genome-wide 5hmC profiling of rare cell populations
Investigations of 5-hydroxymethylcytosine (5hmC) in biologically and clinically samples and models with low cell numbers have been hampered by the low sensitivity and reproducibility using current 5hmC mapping approaches. Here, we develop a selective 5hmC chemical labeling approach using tagmentatio...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-77967 | biostudies-arrayexpress
TranscriptomicsTet2-/-Flt3ITD and WT stem and progenitor cells
The study was a comparison of gene expression using RNA-seq. We analyzed the stem and progenitor cells from WT and Vav-cre+ Tet2fl/fl Flt3-ITD (T2F3) mice. We isolated stem cells LSK (lin- sca+ kit+) and granulocyte-macrophage progenitors GMP (lin- sca- kit+ fcgr+ cd34+) cells from bone marrow. Comp...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-57244 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CD45- and CD45+ cells in the embryonic lung
Side population (SP) cells are highly enriched in stem and progenitor cells. CD45+and CD45- SP cells were found at all developmental lung stages with the highest frequency of cells present at embryonic day 17.5 (E17.5), In order to clarify the role of these cells in lung development, we used oligonu...
ORGANISM(S): Mus musculus 
2007-11-23 | E-GEOD-2057 | biostudies-arrayexpress
TranscriptomicsEccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways
Full title: Eccentric exercise activates novel transcriptional regulation of hypertrophic signaling pathways not affected by hormone changes. Unaccustomed eccentric exercise damages muscle tissue stimulating mechanisms of recovery and remodeling that may be affected by cellular protection by the sex...
ORGANISM(S): Homo sapiens 
2009-12-16 | E-GEOD-19062 | biostudies-arrayexpress
GenomicsInsights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis
The transcription factor GATA-1 is required for terminal erythroid maturation and functions as an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability to distinguish between activated versus repressed genes remain incompletely understood. In this study, we p...
ORGANISM(S): Mus musculus 
2009-11-25 | E-GEOD-16594 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of resistant and susceptible Atlantic salmon fry challenged with Infectious Pancreatic Necrosis virus
Infectious Pancreatic Necrosis (IPN) is a highly contagious birnavirus disease of farmed salmonid fish, which often causes high levels of morbidity and mortality. A large genetic component underlying resistance to this disease has been previously described for Atlantic salmon (Salmo salar L.), which...
ORGANISM(S): Salmo salar 
2016-04-07 | E-MTAB-4275 | biostudies-arrayexpress
TranscriptomicsDefining the Genomic Signature of the Parous Breast
It is widely accepted that a woman’s lifetime risk of developing breast cancer at menopause is reduced by early full term pregnancy and multiparity. This phenomenon is associated with the development and differentiation of the breast, which ultimately imprints a specific genomic profile in the mam...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-26457 | biostudies-arrayexpress
UnknownCytochrome P450 Allele CYP3A7*1C Associates with Adverse Outcomes in Chronic Lymphocytic Leukemia, Breast, and Lung Cancer.
Not available
S-EPMC4795533 | biostudies-literature
GenomicsFLT3-ITD mutations and TET2 loss synergistically alter global DNA methylation in AML
Studies of AML patient samples have shown that specific combinations of AML disease alleles confer an adverse outcome, however, in vivo models do not exist for the majority of common, poor-prognosis genotypes. Here we show that TET2/FLT3 mutations can cooperate to induce AML in vivo using a genetic...
ORGANISM(S): Mus musculus 
2015-04-14 | E-GEOD-57114 | biostudies-arrayexpress
GenomicsHomozygous loss-of-function variants in European cosmopolitan and isolate populations
Homozygous loss of function (HLOF) variants provide a valuable window on gene function in humans, as well as an inventory of the human genes that are not essential for survival and reproduction. All humans carry at least a few HLOF variants, but the exact number of inactivated genes that can be tole...
EGAS00001001606 | EGA
Sort   by:  
 Page size