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MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
TranscriptomicsComprehensive Analysis of Karyotypic Mosaicism between Trophectoderm and Inner Cell Mass
Aneuploidy has been well documented in blastocyst embryos, but prior studies have been limited in scale and/or lack mechanistic data. We previously reported preclinical validation of microarray 24-chromosome preimplantation genetic screening (PGS) in a 24-hour protocol. The method diagnoses chromoso...
ORGANISM(S): Homo sapiens 
2010-09-28 | E-GEOD-22864 | biostudies-arrayexpress
UnknownRandomized Trial of a Web-Based Intervention to Address Barriers to Clinical Trials.
Not available
S-EPMC4872012 | biostudies-literature
UnknownFinancial Concerns About Participation in Clinical Trials Among Patients With Cancer.
Not available
S-EPMC4872013 | biostudies-literature
MetabolomicsMetabolic profiling of rheumatoid arthritis neutrophils reveals altered energy metabolism that is not affected by JAK inhibition
Neutrophils play a key role in the pathophysiology of rheumatoid arthritis (RA) where release of ROS and proteases directly causes damage to joints and tissues. Neutrophil function is directly affected by Janus Kinase (JAK) inhibitor drugs, including tofacitinib and baricitinib, which are clinically...
2023-07-11 | MTBLS4766 | MetaboLights
TranscriptomicsBiopsies from metastatic Clear Cell Renal Carcinoma before or after treatment with nivolumab
Tumor core needle biopsies from kidney or metastatic sites obtained at trial enrollment i.e. Screen and/or at Cycle 2 Day 8 (i.e.Week 4) from metastatic clear cell RCC patients treated with 0.2mpk, 3mpk or 10mpk (as 2nd or further line of therapy; Arms A,B,C) or 10mpk (as first line therapy; Arm D) ...
ORGANISM(S): Homo sapiens 
2016-05-15 | E-MTAB-3218 | biostudies-arrayexpress
TranscriptomicsBlood RNA from metastatic Clear Cell Renal Carcinoma patients before or after treatment with nivolumab
Blood samples obtained at Cycle 1 Day 1, Cycle 1 Day 2 or at Cycle 2 Day 8 (i.e. before treatment, 24 hours after treatment or Week 4) from metastatic clear cell RCC patients treated with 0.2mpk, 3mpk or 10mpk (as 2nd or further line of therapy; Arms A,B,C) or 10mpk (as first line therapy; Arm D) of...
ORGANISM(S): Homo sapiens 
2016-05-15 | E-MTAB-3219 | biostudies-arrayexpress
UnknownPatterns of Clinical Progression in Radiorecurrent High-risk Prostate Cancer.
Not available
S-EPMC10262978 | biostudies-literature
TranscriptomicsEarly CCL2 and CXCL10 chemokine expression correlates with lung pathology in Pandemic H1N1 Influenza A infection
Background: Pandemic H1N1 influenza A is a newly emerging strain of human influenza that is easily transmitted between people and has spread globally to over 116 countries. Human infection leads to symptoms ranging from mild to severe with lower respiratory complications observed in a small but sign...
ORGANISM(S): Mustela putorius furo 
2010-04-12 | E-GEOD-17079 | biostudies-arrayexpress
TranscriptomicsGM-CSF induced gene-regulation in human monocytes
Human and murine studies showed that granulocyte macrophage colony-stimulating factor (GM-CSF) exerts beneficial effects in intestinal inflammation. To explore whether GM-CSF mediates its effects via monocytes, we analyzed effects of GM-CSF on monocytes in vitro and assessed the immunomodulatory pot...
ORGANISM(S): Homo sapiens 
2014-11-27 | E-GEOD-63662 | biostudies-arrayexpress
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