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TranscriptomicsBrucella melitensis global gene expression
In this study we report that B. melitensis at the late logarithmic phase of growth are more invasive for HeLa cells than at mid logarithmic or stationary growth phases. Microarray analysis of B. melitensis gene expression identified 414 up- and 40 down-regulated genes in late-log growth phase compar...
ORGANISM(S): Brucella melitensis 
2010-05-19 | E-GEOD-11192 | biostudies-arrayexpress
TranscriptomicsRole of SPI-1 Secreted Effectors, SipA, SopABDE2, in Acute Bovine Response to Salmonella enterica Serovar Typhimurium
Salmonella enterica Serovar Typhimurium (S. Typhimurium) causes enterocolitis in humans and calves characterized by diarrhea and polymorphonuclear cell (PMN) influx to the intestinal mucosa. The Salmonella Type III Secretion System encoded at Pathogenicity Island I (SPI-1) translocates the Salmonel...
ORGANISM(S): Bos taurus 
2012-01-10 | E-GEOD-13847 | biostudies-arrayexpress
TranscriptomicsBovine Peyer's Patch Infected with Mycobacterium avium ssp. paratuberculosis and Mycobacterium avium ssp. avium
Mycobacterium avium subspecies paratuberculosis (MAP) infection is established following the ingestion of bacteria, their penetration of the intestinal mucosa and subsequent events of the host-parasite interaction. These bacteria invade M cells, macrophages and are capable of resisting host defenses...
ORGANISM(S): Bos taurus 
2012-10-03 | E-GEOD-13888 | biostudies-arrayexpress
TranscriptomicsExpt 2: The contribution of vjbR and N-dodecanoyl homoserine lactone on gene regulation in Brucella melitensis
Quorum sensing (QS) is a communication system in bacteria that regulates gene expression in response to a small diffusible signal indicative of the bacterial population present. QS has been shown to regulate virulence genes, biofilm formation, cell division and secretion systems in a diverse set of...
ORGANISM(S): Brucella melitensis 16M 
2010-04-23 | E-GEOD-13633 | biostudies-arrayexpress
TranscriptomicsExpt 1: The contribution of vjbR and N-dodecanoyl homoserine lactone on gene regulation in Brucella melitensis
Quorum sensing (QS) is a communication system in bacteria that regulates gene expression in response to a small diffusible signal indicative of the bacterial population present. QS has been shown to regulate virulence genes, biofilm formation, cell division and secretion systems in a diverse set of...
ORGANISM(S): Brucella melitensis 16M 
2010-04-23 | E-GEOD-13527 | biostudies-arrayexpress
TranscriptomicsBrucella melitensis-infected HeLa cells gene expression
In a time course study, we characterized global gene expression profile of B. melitensis-infected epithelium-like cells at the onset of infection. B. melitensis-infected HeLa cells exhibited a down-regulated expression profile at 4 h (48 up- and 109 down-regulated genes) that transitioned to an acti...
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-14703 | biostudies-arrayexpress
TranscriptomicsIdentification of MucR regulatory targets
The transcriptional regulator MucR was identified as highly attenuated in a mutagenesis screen conducted by this laboratory. MucR has been described as a key regulator of exopolysaccharide synthesis in closely related Rhizobials soil symbionts. The goal of this study was to apply custom Brucella m...
ORGANISM(S): Brucella melitensis 16M 
2010-04-23 | E-GEOD-13647 | biostudies-arrayexpress
TranscriptomicsIntracellular Brucella melitensis gene expression
Brucella spp. is an intracellular pathogen in vivo. The intracellular B. melitensis transcriptome was determined by initially enriched and then amplified B. melitensis RNA from total RNA of B. melitensis-infected HeLa cells. Analysis of microarray results identified 161 and 115 genes differentially ...
ORGANISM(S): Brucella melitensis 
2012-12-27 | E-GEOD-14704 | biostudies-arrayexpress
TranscriptomicsTemporal gene expression analysis of the Brucella melitensis-infected bovine Peyer's patch
In a time course study, we characterized global gene expression profile of B. melitensis-infected bovine Peyer patches in the first 4 h p.i. Microarray analysis revealed that 2,916 bovine genes were detected as differentially expressed (z-score p < 0.025) in loops inoculated with virulent B. meliten...
ORGANISM(S): Bos taurus 
2013-10-15 | E-GEOD-41835 | biostudies-arrayexpress
UnknownAge-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.
Not available
S-EPMC8631592 | biostudies-literature
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