Sort   by:  
 Page size 
TranscriptomicsRNA-seq of Pseudomonas aeruginosa PAO1 wild-type and ersA (sRNA) knock-out mutant
We investigate the differences in total gene expression between P.aeruginosa PAO1 (wild-type) and ΔersA isogenic mutant. ErsA is a small RNA involved in several P. aeruginosa phenotypes, including biofilm formation and antibiotic resistance. Cells were grown in a rich medium (BHI, Brain Heart Infusi...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2018-02-05 | E-MTAB-6247 | biostudies-arrayexpress
TranscriptomicsFrequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Inflammatory hepatocellular adenomas (IHCA) are benign liver tumours defined by the presence of inflammatory infiltrates and by the elevated expression of inflammatory proteins in tumour hepatocytes1,2. Here we show a striking activation of the IL6 signalling pathway in this tumour type, and sequenc...
ORGANISM(S): Homo sapiens 
2008-12-24 | E-GEOD-11819 | biostudies-arrayexpress
TranscriptomicsHNF1-alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP1 & ChREBP activation
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1a (HNF1a), were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. To understand the molecular basis of this aberrant lipid storage, w...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-7473 | biostudies-arrayexpress
TranscriptomicsChronic myelogenous leukemia hematopoietic stem cells
We show the molecular and functional characterization of a novel population of lineage-negative CD34-negative (Lin- CD34-) hematopoietic stem cells (HSCs) from chronic myelogenous leukemia (CML) patients at diagnosis. Molecular caryotyping and quantitative analysis of BCR/ABL transcript demonstrated...
ORGANISM(S): Homo sapiens 
2010-01-04 | E-GEOD-11675 | biostudies-arrayexpress
TranscriptomicsSox9 duplications cause Sry-negative XX sex-reversal in dogs
Sexual development in mammals is based on a complicated and delicate network of genes and hormones that have to collaborate in a precise manner. The dark side of this pathway is represented by pathological conditions, wherein sexual development does not occur properly either in the XX and the XY bac...
ORGANISM(S): Canis lupus familiaris 
2014-08-05 | E-GEOD-57137 | biostudies-arrayexpress
UnknownDNA methylation-based prognosis and epidrivers in hepatocellular carcinoma.
Not available
S-EPMC12337117 | biostudies-literature
TranscriptomicsTranscription profiling by array of human bone marrow hematopoietic stem cells from healthy young and elderly individuals
In the human hematopoietic system, aging is associated with decreased bone marrow cellularity, decreased adaptive immune system function, and increased incidence of anemia and other hematological disorders and malignancies. Recent studies in mice suggest that changes within the hematopoietic stem ce...
ORGANISM(S): Homo sapiens 
2011-11-11 | E-GEOD-32719 | biostudies-arrayexpress
TranscriptomicsVectorial secretion of interleukin-8 (IL-8 or CXCL8) mediates homeostatic effects on the intestinal epithelium via apically located CXCR1
CXCL8 is produced by many cell types including epithelial, endothelial, fibroblasts and macrophages in response to TLR recognition of microbe-associated molecular patterns (MAMPs) or inflammatory cytokines and recruits phagocytes from the vasculature to sites of infection via interaction with its co...
ORGANISM(S): Homo sapiens 
2014-06-28 | E-GEOD-30364 | biostudies-arrayexpress
UnknownMicroRNA expression profiles in molecular subtypes of clear-cell renal cell carcinoma are associated with clinical outcome and repression of specific mRNA targets.
Not available
S-EPMC7485767 | biostudies-literature
TranscriptomicsTranscription profiling of long-term hematopoietic stem cells from old and young mice to investigate the mechanisms of hematopoietic aging
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties...
ORGANISM(S): Mus musculus 
2007-12-19 | E-GEOD-4332 | biostudies-arrayexpress
Sort   by:  
 Page size