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UnknownClinical utility of a plasma-based miRNA signature classifier within computed tomography lung cancer screening: a correlative MILD trial study.
Not available
S-EPMC4876348 | biostudies-literature
UnknownCD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia.
Not available
S-EPMC4876311 | biostudies-literature
TranscriptomicsExpression data from untreated and ATP treated AML blasts
In the present study, we investigated whether, and to what extent, P2Rs and their ligands are involved in the regulation of AML cells. Our findings show that AML blasts express several receptors belonging to the P2X and P2Y family. Although different samples respond differently to ATP and UTP stimul...
ORGANISM(S): Homo sapiens 
2012-02-25 | E-GEOD-30903 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34+ cells and treatment with UTP and CXCL12
Homing and engraftment of hematopoietic stem cells (HSCs) to the bone marrow (BM) involve a complex interplay between chemokines, cytokines, and non-peptide molecules. Extracellular nucleotides and their cognate P2 receptors are emerging as key-factors of inflammation and related chemotactic respons...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5168 | biostudies-arrayexpress
TranscriptomicsExtracellular purines promote the differentiation capacity of human bone marrow-derived mesenchymal stem cells
Extracellular nucleotides are potent signaling molecules mediating cell-specific biological functions. We previously demonstrated that adenosine 5'-triphosphate (ATP) inhibits the proliferation while stimulating the migration, in vitro and in vivo, of human bone marrow-derived mesenchymal stem cells...
ORGANISM(S): Homo sapiens 
2013-04-11 | E-GEOD-37237 | biostudies-arrayexpress
GenomicsHigh density copy number analysis and whole exome sequencing of chronic lymphocytic leukemia

The pathogenesis of chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is still largely unknown since the full spectrum of genetic lesions that are present in the CLL genome, and therefore the number and identity of dysregulated cellular pathways, have not been iden...

phs000364.v1.p1 | EGA
GenomicsDrug-perturbation-based stratification of blood cancer
As new generations of targeted therapies emerge and tumor genome sequencing discovers increasingly comprehensive mutation repertoires, the functional relationships of mutations to tumor phenotypes remain largely unknown. Here, we measured ex vivo sensitivity of 246 blood cancers to 63 drugs alongsid...
EGAS00001001746 | EGA
TranscriptomicsMolecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to nf-kb pathway inhibition
Molecular profiling of blastic plasmacytoid dendritic cell neoplasm reveals a unique pattern and suggests selective sensitivity to nf-kb pathway inhibition To better understand the pathobiology of BPDCN and discover new targets for effective therapies, the gene expression profile (GEP) of 25 BPDCN s...
ORGANISM(S): Homo sapiens 
2014-10-03 | E-GEOD-62014 | biostudies-arrayexpress
TranscriptomicsSLAMF1/CD150 regulates chemotaxis, autophagy and therapy responses in chronic lymphocytic leukemia patients
This work shows that signaling-lymphocytic-activation-molecule-1 (SLAMF1), a co-stimulatory molecule and a microbial sensor, is expressed by normal CD19+/CD5+ B-lymphocytes. Its expression is lost in a subset of patients with chronic lymphocytic leukemia (CLL) characterized by an aggressive form of ...
ORGANISM(S): Homo sapiens 
2015-05-23 | E-GEOD-69165 | biostudies-arrayexpress
TranscriptomicshMSC ATP treatment
Nucleotides triphosphates are extracellular messengers binding to specific plasma membrane receptors (P2Rs) that modulate responses as different as proliferation, differentiation, migration or cell death on several cell types including hematopoietic stem cells. Little and controversial information i...
ORGANISM(S): Homo sapiens 
2013-04-11 | E-GEOD-14566 | biostudies-arrayexpress
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