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Genomicsena-DATASET-IP-27-09-2016-09:44:13:032-494 - samples
We recruited 100 healthy, male donors of self-reported European descent (EUB) and 100 of self-reported African descent (AFB) (Ghent, Belgium). For each participant, peripheral blood mononuclear cells (PBMCs) were isolated from whole blood on Ficoll-Paque density gradients. Monocytes were then positi...
EGAD00001002714 | EGA
GenomicsGenome-wide genotyping data and exome sequencing of 100 European-descent and 100 African-descent Belgians used in the EGAS000010
The 100 European-descent (EUB) and 100 African-descent (AFB) Belgians studied were genotyped for a total of 4,301,332 SNPs on the Illumina HumanOmni5-Quad BeadChips. Whole-exome sequencing was carried out for the same 200 individuals with the Nextera Rapid Capture Expanded Exome kit, on the Illumina...
EGAD00010001131 | EGA
GenomicsGenetic control of the transcriptomic response of monocytes to bacterial and viral stimuli assessed by RNA-seq in Africans and Europeans
Humans differ in the outcome that follows exposure to life-threatening pathogens, yet the extent of population differences in immune responses, and their genetic and evolutionary determinants, remain undefined. Here, we characterized, using RNA-sequencing, the transcriptional response of primary mon...
EGAS00001001895 | EGA
GenomicsUganda Genotypes - samples
HumanOmni1-Quad genotyping array
EGAD00010000616 | EGA
GenomicsMETPYGAGR_methylation - samples
Genome-wide DNA methylation epigenotyping of African rainforest hunter-gatherers and neighbouring agriculturalists by Illumina HumanMethylation450
EGAD00010000692 | EGA
GenomicsPygAgrMap - samples
Genome-wide SNP genotyping of African rainforest hunter-gatherers and neighbouring agriculturalists
EGAD00010000496 | EGA
GenomicsMETPYGAGR_genotyping - samples
Genome-wide SNP genotyping of African rainforest hunter-gatherers and neighbouring agriculturalists by Illumina HumanOmniExpress
EGAD00010000690 | EGA
GenomicsGenome-wide SNP genotyping of Central African rainforest hunter-gatherers and neighbouring agriculturalists
The emergence of agriculture in West-Central Africa, ~5,000 years ago, profoundly modified the cultural landscape and mode of subsistence of most sub-Saharan populations. How this major innovation has impacted the genetic history of rainforest hunter-gatherers — historically referred to as “pygmies”...
EGAS00001000605 | EGA
GenomicsEvolution of the African pygmy phenotype
The evolutionary history of the human ‘pygmy’ phenotype (small body size), a characteristic of African and Southeast Asian rainforest hunter-gatherers, is largely unknown. Here we use a genome-wide admixture mapping analysis to identify 16 genomic regions that are significantly associated with the p...
EGAS00001000908 | EGA
GenomicsGenome-wide SNP genotyping and DNA methylation epigenotyping of African rainforest hunter-gatherers and neighbouring agriculturalists
The epigenomic landscape of the human genome, in particular DNA methylation, is increasingly recognised as an important driver of phenotypic diversity in health and disease. However, the impact that genetic variation and changes in lifestyle and ecological habitat have on this epigenetic mark remain...
EGAS00001001066 | EGA
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