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TranscriptomicsEffects of pulp and paper mill effluents on gene expression in the fathead minnow hypothalamus
We evaluated the possible mechanisms by which exposures to pulp and paper mill effluents gene expression in the fathead minnow hypothalamus Keywords: Toxicology Sexually mature fathead minnows were exposed to 100% pulp and paper mill effluents for 5 days. Tanks contained 4 females and 2 males. A ...
ORGANISM(S): Pimephales promelas 
2010-07-07 | E-GEOD-17130 | biostudies-arrayexpress
TranscriptomicsTranscription profiling validation of an custom mouse oligo array using liver samples following treatment with the hepatotoxin phenobarbital and variable hybridization protocols
The use of custom-made focused microarrays has become a popular alternative, allowing the study of genes relevant to a specific hypothesis. To address the limitations of commercial arrays in toxicogenomics investigations, we have developed a custom mouse oligonucleotide microarray, the HC ToxArrayTM...
ORGANISM(S): Mus musculus 
2006-10-30 | E-MEXP-525 | biostudies-arrayexpress
TranscriptomicsThe effect of bisphenol A on human preadipocyte differentiation.
Background: Exposure to the endocrine-disrupting chemical bisphenol A (BPA) is correlated with obesity and promotes adipogenesis of human preadipocytes into mature adipocytes. However, the mechanism of action of BPA-induced human adipogenesis in vitro remains to be fully characterized. Methods: In t...
ORGANISM(S): Homo sapiens 
2014-04-15 | E-GEOD-56085 | biostudies-arrayexpress
TranscriptomicsLack of hepatic response of microRNA in mice following DB[a,h]A exposure (Agilent miRNA)
Dibenzo[a,h]anthracene DB[a,h]A is a polycyclic aromatic hydrocarbon potent carcinogen. Few studies have investigated the role of DB[a,h]A on mRNA and miRNA expression. In this study a 10-week old male MutaTM Mouse were exposed to 6.25, 12.5, and 25 mg/kg/day DB[a,h]A by oral gavage for 28 cons...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-35195 | biostudies-arrayexpress
TranscriptomicsLack of hepatic response of microRNA in mice following DB[a,h]A exposure (Agilent expression)
Dibenzo[a,h]anthracene DB[a,h]A is a polycyclic aromatic hydrocarbon potent carcinogen. Few studies have investigated the role of DB[a,h]A on mRNA and miRNA expression. In this study a 10-week old male MutaTM Mouse were exposed to 6.25, 12.5, and 25 mg/kg/day DB[a,h]A by oral gavage for 28 cons...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-35215 | biostudies-arrayexpress
TranscriptomicsMice Exposed in situ to Urban Air Pollution Exhibit Pulmonary Alterations in Lipid Droplet Synthesis Pathways
In the present study, we investigate pulmonary transcriptional responses in mice following exposure in situ to ambient air in a heavily polluted urban environment. Mature C57BL/CBA male mice were caged in sheds located in an urban area near two working steel mills and a major highway in Hamilton, On...
ORGANISM(S): Mus musculus 
2013-09-30 | E-GEOD-41698 | biostudies-arrayexpress
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