Rpa2 - OmicsDI

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Unknown (116)
Transcriptomics (26)
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biostudies-arrayexpress (22)
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Disease

HPV positive (1)
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Technology Type

Mass Spectrometry (8)
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Affinity purification coupled with mass spectrometry proteomics (3)
Illumina HiSeq 2000 (1)
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Top-down proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (3)
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Illumina HiSeq 2000 (1)
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Publication Date

2023 (7)
2024 (4)
2014 (4)
2011 (4)
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2016 (3)
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2020 (2)
2017 (2)
2010 (2)
2022 (2)
2008 (1)
2007 (1)
2005 (1)

CHEBI ID

CHEBI:180628 (1)
CHEBI:180627 (1)
CHEBI:89514 (1)
CHEBI:180626 (1)
CHEBI:180625 (1)
CHEBI:180624 (1)
CHEBI:86090 (1)
CHEBI:34575 (1)
CHEBI:180623 (1)
CHEBI:90693 (1)
CHEBI:180622 (1)
CHEBI:180621 (1)
CHEBI:180620 (1)
CHEBI:31108 (1)
CHEBI:163908 (1)
CHEBI:180619 (1)
CHEBI:57784 (1)
CHEBI:180618 (1)
CHEBI:158093 (1)
CHEBI:75018 (1)
CHEBI:28392 (1)
CHEBI:180617 (1)
CHEBI:164847 (1)
CHEBI:180616 (1)
CHEBI:180615 (1)
CHEBI:180614 (1)
CHEBI:180613 (1)
CHEBI:5320 (1)
CHEBI:180612 (1)
CHEBI:180611 (1)

Metabolite Name

P-Vinylbiphenyl (1)
Oxalic acid-guanidine (1/1) (1)
1,6-di-o-phosphonohex-2-ulofuranose (1)
Dibutyl terephthalate (1)
(R)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid (1)
L-Glutarylcarnitine (1)
4,4'-Methylenediphenol (1)
Dehydrofelodipine (1)
U-0126 (1)
Methyl 3,4,6-tri-O-acetyl-2-deoxy-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-thiohexopyranoside (1)
N'-[2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-4-nitrobenzohydrazide (1)
1-(3-Isocyanatophenyl)-5-(methylsulfanyl)-1H-tetrazole (1)
Gly-Met-Val (1)
3-Aminopentanoic acid (1)
2-[3-Carboxy-3-(methylammonio)propyl]-L-histidine (1)
Ala-Ala-Gly-Ala (1)
Ala-Gln-Ala (1)
4-Dedimethylamine-4-oxo-anhydro-7-Cl-tetracycline (1)
Trp-Ser-Pro (1)
Gly-Gly-Thr-Tyr (1)
4-Hydroxy-5-phenyl-1,3-oxazinan-2-one (1)
3,4-Methylenedioxybenzyl methyl ketoximine (1)
Methyl 4,4,4-trifluoro-3-hydroxy-3-methoxybutanoate (1)
Thr-Tyr-Gly-Gly (1)
Gentioflavine (1)
Asp-Thr-His-Gly (1)
Acetic acid-1-(2-ethoxyethoxy)ethan-1-ol (1/1) (1)
Terestigmine (1)
Glu-Cys-Gly (1)
2-Deoxy-2,3-didehydro-N-glycoloylneuraminic acid (1)

First Public Date

2023 (3)
2026 (2)
2025 (2)
2024 (2)
2022 (1)
2017 (1)
2014 (1)

Study type

Transcription profiling by array (15)
RNA-seq of coding RNA from single cells (3)
MNase-seq (1)
Cell line - High-throughput sequencing (1)
Transcription profiling by RT-PCR (1)
RNA-seq of coding RNA (1)

Release Date

2024 (12)
2022 (12)
2021 (12)
2023 (11)
2025 (11)
2014 (10)
2016 (9)
2020 (8)
2010 (7)
2019 (7)
2011 (6)
2015 (6)
2009 (5)
2018 (4)
2017 (3)
2008 (3)
2013 (3)
2012 (3)
2007 (2)
2006 (2)
2026 (1)
2004 (1)

Lab affiliation

Institute for Cardiovascular Physiology, Faculty of Medicine, Goethe-University; Frankfurt am Main, Germany (2)
., Department of Laboratory Medicine, Medical University of Vienna, 18-20 Währinger Gürtel, 1090 Vienna, Austria (1)
Chromatin Biology Laboratory, Josep Carreras Leukaemia Research Institute (IJC), Ctra de Can Ruti, Camí de les Escoles s/n, 08916, Badalona, Barcelona, Spain (1)
Department of Molecular Mechanisms of Disease, University of Zurich (UZH), Zurich, Switzerland (1)
School of Life Sciences, Ulsan National University of Science and Technology (UNIST), Ulsan 44919, Republic of Korea (1)
Sherbrooke University, Immunology and cellular biology department, FMSS (1)
University of Copenhagen (1)

Tags

xref:PubMed:16943533 (1)
xref:PubMed:16467079 (1)
xref:PubMed:40240347 (1)
xref:PubMed:39185212 (1)
xref:PubMed:39178742 (1)
xref:PubMed:28107649 (1)

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O-GlcNAcylation of RPA2 at S4/S8 antagonizes phosphorylation and regulates checkpoint activation during replication stress

O-linked N-acetylglucosamine (O-GlcNAc) is the only mono-saccharide modification occurring in the cytoplasm, nucleus and mitochondria. Recent advent of the mass spectrometry technology has enabled identification of abundant O-GlcNAc transferase (OGT) substrates in diverse biological processes, such ...

ORGANISM(S): Homo Sapiens

2024-06-21 | PXD053321 |

Genome stability disrupted by the circRBM39-RPA2 axis represses breast tumorigenesis

PRJNA1224764 | ENA

Upregulated RPA2 in endometrial tissues of repeated implantation failure patients impairs the endometrial decidualization.

Not available

S-EPMC10643753 | biostudies-literature

HERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation.

Not available

S-EPMC6776656 | biostudies-literature

Translational regulation of RPA2 via internal ribosomal entry site and by eIF3a.

Not available

S-EPMC3670257 | biostudies-literature

Genome stability disrupted by the circRBM39-RPA2 axis represses breast tumorigenesis

Genome instability (GI) is a hallmark of cancer. GI is associated with accumulative DNA damage and tumor-specific defects in DNA repair. Multiple anti-tumor drugs have been developed to promote persistent GI and to drive DNA damage beyond a threshold that tumor cells can survive. However, regulatory...

ORGANISM(S): Homo sapiens

2025-02-22 | GSE289776 | GEO

DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange.

Not available

S-EPMC3120867 | biostudies-literature

Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cells.

Not available

S-EPMC4787776 | biostudies-literature

Phospho-RPA2 predicts response to platinum and PARP inhibitors in homologous recombination-proficient ovarian cancer.

Not available

S-EPMC12208538 | biostudies-literature

TTK activates ATR through RPA2 phosphorylation to promote olaparib resistance in ovarian cancer.