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Transcriptional profiling of human hTERT-RPE1 cell spheroids comparing Control siRNA transfected hTERT-RPE1 cell spheroids with those transfected with YAP1 siRNA. Two-condition experiment, Control siRNA vs.YAP1 siRNA hTERT-RPE1 cell spheroids. Biological replicates: 1 Control siRNA, 1YAP1 siRNA tran...
ORGANISM(S): Homo sapiens 
Primary cilium serves as a cellular M-bM-^@M-^\antennaM-bM-^@M-^] to sense environmental signals. Ciliogenesis requires the removal of CP110 to convert the mother centriole into the basal body. Actin dynamics is also critical for cilia formation. How these distinct processes are properly regulated r...
ORGANISM(S): Homo sapiens 
Histone deacetylase (HDAC) inhibitors are part of a new generation of epigenetic drugs for cancer treatment. It is known that histone acetylation plays a key role in controlling essential chromosome functions, including gene regulation, and this process has been linked with cancer development and pr...
2022-05-04 | MTBLS682 | MetaboLights
RNA-seq in human RPE1-hTERT cells
mRNA sequencing of RPE1-TP53KO and RPE1-TP53KO-EIF2AKO cells
RNA-seq upon MYCN activation in the hTERT-immortalized MYCN retinal pigmented epithelial cell line (RPE1–MYCN-ER). The parental hTERT-immortalized retinal pigment epithelium (hTERT-RPE1) was used as a control as this cell line does not carry the MYCN:ER expression construct. Both cell lines were tre...
ORGANISM(S): Homo sapiens 
Expression analysis of RPE1-TP53KO cells with ESCO2mut, DDX11KO and PAXIP1KO
Single-cell DNA sequencing was performed using the Mission Bio Tapestri platform to analyze ecDNA-associated copy-number dynamics across cancer cell lines, single-cell-derived clones, and drug-treated conditions. Droplet-based targeted PCR amplification was carried out according to the manufacturer’...
ORGANISM(S): Homo sapiens 
RPE1 cells that were either WT or Cdh1 mutant were treated with and without the AurKB inhibitor Barasertib, and assessed by phosphoproteomic analysis
ORGANISM(S): Homo sapiens (Human) 
2023-10-12 | PXD044042 | Pride
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