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TranscriptomicsSnapshots of pre-rRNA structural flexibility reveal eukaryotic 40S assembly dynamics at nucleotide resolution
Ribosome assembly in eukaryotes involves the activity of hundreds of assembly factors that direct the hierarchical assembly of ribosomal proteins and numerous ribosomal RNA folding steps. However, detailed insights into the function of assembly factors and ribosomal RNA folding events are lacking. T...
ORGANISM(S): Saccharomyces cerevisiae 
2014-11-14 | E-GEOD-52878 | biostudies-arrayexpress
ProteomicsA comprehensive view on r- protein binding and rRNA domain structuring during early ribosome formation
Formation of the eukaryotic ribosomal subunits follows a strict regime to assemble ribosomal proteins (r-protein) with ribosomal RNAs (rRNA) while removing internal (ITS) and external (ETS) transcribed rRNA spacers. During early stages of large subunit (LSU) formation, ITS2 together with six assembl...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-02-02 | PXD058994 | Pride
Ribosome biogenesis Single particle cryo-em Lsu assembly Ssu processome Rrna domain folding Ribosomal protein assembly 
UnknownProtein folding by domain V of Escherichia coli 23S rRNA: specificity of RNA-protein interactions.
Not available
S-EPMC2347393 | biostudies-literature
OtherHigh-throughput RNA structure probing reveals critical folding events during early 60S ribosome assembly in yeast.
While the protein composition of various yeast 60S ribosomal subunit assembly intermediates has been studied in detail, little is known about ribosomal RNA (rRNA) structural rearrangements that take place during early 60S assembly steps. Using a high-throughput RNA structure probing method, we provi...
ORGANISM(S): Saccharomyces cerevisiae 
2017-10-04 | GSE83821 | GEO
UnknownShape changes and cooperativity in the folding of the central domain of the 16S ribosomal RNA.
Not available
S-EPMC7958424 | biostudies-literature
ProteomicsH/ACA snR30 snoRNP guides independent 18S rRNA subdomain formation – Dataset 2
Ribosome biogenesis follows a hierarchical set of pre-ribosomal RNA (pre-RNA) folding and processing steps. The earliest, biochemically stable pre-ribosome is the 90S particle, which is assembled co-transcriptionally in the nucleolus. It is unclear how pre-rRNA, ribosomal proteins and assembly facto...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-22 | PXD054032 | Pride
Yeast Snornp Ribosome biogenesis 
ProteomicsH/ACA snR30 snoRNP guides independent 18S rRNA subdomain formation – Dataset 4
Ribosome biogenesis follows a hierarchical set of pre-ribosomal RNA (pre-RNA) folding and processing steps. The earliest, biochemically stable pre-ribosome is the 90S particle, which is assembled co-transcriptionally in the nucleolus. It is unclear how pre-rRNA, ribosomal proteins and assembly facto...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-22 | PXD054035 | Pride
Yeast Snornp Ribosome biogenesis 
ProteomicsH/ACA snR30 snoRNP guides independent 18S rRNA subdomain formation – Dataset 3
Ribosome biogenesis follows a hierarchical set of pre-ribosomal RNA (pre-RNA) folding and processing steps. The earliest, biochemically stable pre-ribosome is the 90S particle, which is assembled co-transcriptionally in the nucleolus. It is unclear how pre-rRNA, ribosomal proteins and assembly facto...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-22 | PXD054034 | Pride
Yeast Snornp Ribosome biogenesis 
ProteomicsH/ACA snR30 snoRNP guides independent 18S rRNA subdomain formation – Dataset 1
Ribosome biogenesis follows a hierarchical set of pre-ribosomal RNA (pre-RNA) folding and processing steps. The earliest, biochemically stable pre-ribosome is the 90S particle, which is assembled co-transcriptionally in the nucleolus. It is unclear how pre-rRNA, ribosomal proteins and assembly facto...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-05-22 | PXD054031 | Pride
Yeast Snornp Ribosome biogenesis 
ProteomicsThe RNA helicase Dbp7 promotes domain V/VI compaction and stabilization of inter-domain interactions during early 60S assembly
Early pre-60S ribosomal particles are poorly characterized, highly dynamic complexes that undergo extensive rRNA folding and compaction concomitant with assembly of ribosomal proteins and exchange of assembly factors. Pre-60S particles contain numerous RNA helicases, which are likely regulators of a...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-08-23 | PXD022625 | Pride
Small nucleolar rna Ribosomal protein. Ribosome biogenesis Rna helicase 
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