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GenomicsMicrobiota modulate transcription in the intestinal epithelium without remodeling the accessible chromatin landscape
We profiled transcriptome and accessible chromatin landscapes in intestinal epithelial cells (IECs) from mice reared in the presence or absence of microbiota. We show that regional differences in gene transcription along the intestinal tract were accompanied by major alterations in chromatin organiz...
ORGANISM(S): Mus musculus 
2014-06-07 | E-GEOD-57919 | biostudies-arrayexpress
GenomicsThe transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer
Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, fundamental steps in the initiation of human cancer. Multiple cancer types, including up to 83% of glioblastomas (GBM), harbor highly recurrent TERT promoter mut...
EGAS00001001242 | EGA
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