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TranscriptomicsCharaterization of genetic alterations and gene expression signatures found in BCR-ABL inhibitor-resistant KCL-22 subpopulations and single clones
KCL-22 is a chronic myeloid leukemia (CML) cell line derived from a patient in blast crisis phase and harbors the BCR-ABL translocation. The catalytic (ATP-competitive) BCR-ABL inhibitors imatinib and nilotinib have dramatically improved CML patient outcome, but the development of resistance remains...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-62121 | biostudies-arrayexpress
TranscriptomicsCharaterization of genetic alterations and gene expression signatures found in erlotinib-resistant and erlotinib/crizotinib dual-resistant HCC827 subpopulations
The non-small cell lung cancer (NSCLC) cell line HCC827 harbors an activating EGFR mutation (exon 19 deletion) that confers sensitivity to the FDA-approved EGFR inhibitor erlotinib. By applying the ClonTracer barcoding system, we were able to show the presence of pre-existing sub-populations in HCC8...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-62118 | biostudies-arrayexpress
UnknownDeveloping Consensus on Clinical Outcomes for Children with Mild Pneumonia: A Delphi Study.
Not available
S-EPMC9969329 | biostudies-literature
UnknownAI-based Hepatic Steatosis Detection and Integrated Hepatic Assessment from Cardiac CT Attenuation Scans Enhances All-cause Mortality Risk Stratification: A Multi-center Study.
Not available
S-EPMC12204434 | biostudies-literature
UnknownBiallelic CRELD1 variants cause a multisystem syndrome, including neurodevelopmental phenotypes, cardiac dysrhythmias, and frequent infections.
Not available
S-EPMC10932913 | biostudies-literature
UnknownAdjuvant Olaparib for Patients with <i>BRCA1</i>- or <i>BRCA2</i>-Mutated Breast Cancer.
Not available
S-EPMC9126186 | biostudies-literature
UnknownAssociation analysis identifies 65 new breast cancer risk loci.
Not available
S-EPMC5798588 | biostudies-literature
UnknownPolygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes.
Not available
S-EPMC6323553 | biostudies-literature
UnknownCommon, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity.
Not available
S-EPMC8661833 | biostudies-literature
UnknownMapping the human genetic architecture of COVID-19.
Not available
S-EPMC8674144 | biostudies-literature
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