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ModelsPassos2010_DNAdamage_CellularSenescence
This is the model described in: Feedback between p21 and reactive oxygen production is necessary for cell senescence. Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslagers S, Hallinan J, Wipat A, Saretzki G, Rudolph KL, Kirkwood TB, von Zglinicki T. ;M...
2024-09-02 | BIOMD0000000287 | BioModels
ProteomicsRad21-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation
MTD project_description Inflammation and decreased stem cell function characterize organism aging, yet the relationship between these factors remains incompletely understood. This study shows that aged hematopoietic stem and progenitor cells exhibit increased ground-stage NF-κB activity, which enhan...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-28 | PXD011537 | Pride
Hematopoietic stems cells Inflammation Aging 
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