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TranscriptomicsTranscriptional response of mouse thyroids following in vivo 211At exposure reveals distinct gene expression profiles
Transcriptomic profiling of normal mouse thyroid tissue following 211At irradiation Astatine-211 (211At) is an alpha particle emitting halogen with almost optimal linear energy transfer (LET) for creating DNA double strand breaks, and is thus proposed for radionuclide therapy when bound to tumor-see...
ORGANISM(S): Mus musculus 
2013-02-13 | E-GEOD-32306 | biostudies-arrayexpress
TranscriptomicsComparative analysis of transcriptional gene regulation indicates similar physiological response in mouse tissues at low absorbed doses from i.v. administered 211At
Transcriptomic profiling of normal mouse lung, liver, kidney, and spleen tissue following 211At irradiation. Total RNA was isolated from fresh-frozen tissue samples.
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-40806 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses to i.v. administered I-131 in various mouse normal tissues underlie diurnal variation
Circadian rhythm study on transcriptional responses to i.v. administered 90 kBq iodine-131 after 24h in mouse kidney cortex and medulla, liver, lungs, spleen, and thyroid. Female BALB/c nude mice (n=4/group) were i.v. injected with 90 kBq 131I at three different times of day, i.e. at 9.00 am, at 12....
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-66303 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses in various normal mouse tissues after 24 h following 4 MV photon beam irradiation using three partial body irradiation set-ups
Female BALB/c nude mice (n=3/group) were subjected to partial body irradiation under anesthesia using 2 Gy external photon (4 MV, nominal) irradiation. In group A, the collum (i.e. the thyroid) was irradiated; in group B, thorax+abdomen were irradiated, and in group C, collum+thorax+abdomen were irr...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-66372 | biostudies-arrayexpress
TranscriptomicsIodine-131 Biomarker Identification in the Rat Thyroid Gland
Introduction Iodine-131 (131I) is frequently used in nuclear medicine. Unbound or released 131I accumulate in the thyroid gland and may be detrimental to normal thyroid function. The aim of the present study was to identify biomarkers for 131I exposure in rat thyroid tissue and to assess the effect...
ORGANISM(S): Rattus norvegicus 
2016-06-30 | E-GEOD-66623 | biostudies-arrayexpress
TranscriptomicsTranscriptional response in normal tissues in mice after 211At administration - dependency of absorbed dose, dose-rate and time
RNA microarray analysis of low-dose and dose rate responses versus time after i.v. administration of 211At. Female BALB/c nude mice were intravenously injected with 1.7 kBq 211At and killed after 1 h, 6 h, or 7 d, or injected with 105 or 7.5 kBq and killed after 1 h and 6 h, respectively. Controls w...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-56894 | biostudies-arrayexpress
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