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Distinct integration patterns of different retroviruses have puzzled virologists for over 20 years. The viral integrase (IN), as part of the intasome complex, docks onto the target DNA (tDNA) and catalyzes the insertion of the viral genome into the host chromatin. We identified retroviral IN amino a...
ORGANISM(S): Homo sapiens 
To identify mechanisms involved in growth and glucose metabolism, we performed whole genome mRNA expression analysis in five week old quadraceps muscle from 2 CD-1 background male Lin28A Tg and 2 WT littermates (all male) in which there was 7 fold overexpression of Lin28A, a RNA binding protein that...
ORGANISM(S): Mus musculus 
Background: Sepsis therapy is still limited to the treatment of the underlying infection and supportive measures. Therapeutic options that address the molecular changes of sepsis have not yet been identified. With the aim of a future individualized therapy, we used unsupervised machine learning (ML)...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD058562 | Pride
Background The heterogeneity of sepsis represents a major problem for the development of personalized sepsis therapies. Thus, sepsis subtyping emerged as an important tool to approach this problem, but little progress was made due to insufficient molecular insights. Modern proteomics techniques allo...
ORGANISM(S): Homo sapiens (Human) 
2025-09-04 | PXD064125 | Pride
Understanding how RNA binding proteins control the splicing code is fundamental to human biology and disease. Here we present a comprehensive study to elucidate how heterogeneous nuclear ribonucleoparticle (hnRNP) proteins, among the most abundant RNA binding proteins, coordinate to regulate alterna...
ORGANISM(S): Homo sapiens 
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