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GenomicsSMiLE-seq sequencing data (illumina) of human transcription factors profiled in the Codebook/GRECO-BiT collaboration
We assayed 284 human transcription factors (TFs) for DNA binding using selective microfluidics-based ligand enrichment followed by sequencing (SMiLE-seq). These experiments were part of the Codebook/GRECO-BiT collaboration aiming to identify the DNA binding sites of yet-uncharacterized TFs. All data...
ORGANISM(S): synthetic construct 
2024-11-11 | E-MTAB-14598 | biostudies-arrayexpress
GenomicsMethylation-sensitive SMiLE-seq sequencing data (illumina) of human transcription factors profiled in the Codebook/GRECO-BiT collaboration
We assayed 114 human transcription factors (TFs) for DNA binding using methylation-sensitive selective microfluidics-based ligand enrichment followed by sequencing (meSMiLE-seq). Across 23 experiments, we identified DNA binding sites for 48 TFs. Among these, 13 showed aversion towards methylated DNA...
ORGANISM(S): synthetic construct 
2024-11-11 | E-MTAB-14597 | biostudies-arrayexpress
TranscriptomicsMetabolic effects of chronic dihydronicotinamide riboside (NRH) administration in mice - RNA-seq of murine tissues (NRH treatment)
NAD+ is a crucial cofactor for the activity of various enzymes, including sirtuins and ADP-ribosyl transferases, and its decline is associated with aging and metabolic-related diseases. Therefore, a strong interest has been raised in the therapeutic use of NAD+ precursors (Vitamin B3s), but many suf...
ORGANISM(S): Mus musculus 
2026-03-09 | E-MTAB-14195 | biostudies-arrayexpress
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