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GenomicsHes6 expression is controlled by c-Myc and the AR to promote E2F1 activity and poor outcome in castrate-resistant prostate cancer (E2F1 ChIP-seq)
Hes6 is a transcription co-factor that is associated with stem cell characteristics in neural tissue, but its role in cancer remains uncertain. Here we show that Hes6 is controlled by c-Myc and the AR and can drive castration resistance in xenografts of the androgen-dependent LNCaP prostate cancer c...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-36614 | biostudies-arrayexpress
UnknownInhibition of prolyl 4-hydroxylase decreases muscle fibrosis following chronic rotator cuff tear.
Not available
S-EPMC5301902 | biostudies-literature
TranscriptomicsmiRNA alterations are an important mechanism in the adaptation of maize to a low-phosphate environment
Maize is a globally important food and feed crop, and a low-phosphate (Pi) supply in the soil frequently limits maize yield in many areas. MicroRNAs (miRNAs) play important roles in the development and adaptation of plants to the environment. In this study, the spatio-temporal miRNA transcript profi...
ORGANISM(S): Zea mays 
2015-07-08 | E-GEOD-70612 | biostudies-arrayexpress
TranscriptomicsHes6 drives a network with therapeutic potential in castrate-resistant prostate cancer
Castrate-resistant prostate cancer (CRPC) is poorly characterized and heterogeneous and while the androgen receptor (AR) is of singular importance in early prostate cancer, other factors such as c-Myc and the E2F family also play a role in later stage disease. Hes6 is a transcription co-factor that ...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-36526 | biostudies-arrayexpress
UnknownCrosstalk Between Pyroptosis and Apoptosis in Hepatitis C Virus-induced Cell Death.
Not available
S-EPMC8882739 | biostudies-literature
GenomicsHes6 drives a critical AR transcriptional program to induce castration resistant prostate cancer through activation of an E2F1-mediated cell cycle network
Castrate-resistant prostate cancer (CRPC) is poorly characterized and heterogeneous and while the androgen receptor (AR) is of singular importance, other factors such as c-Myc and the E2F family also play a role in later stage disease. Here we show that Hes6 is up-regulated in aggressive human prost...
ORGANISM(S): Homo sapiens 
2014-04-17 | E-GEOD-49832 | biostudies-arrayexpress
TranscriptomicsGenomeTiling
Samples were purchased from Clontech as mRNA. Hybridization material was generated through a random-priming amplification procedure (RP-AMP) using primers with a random sequence at the 3' end and a fixed motif at the 5' end. shDNP256 (first strand synthesis): 5'- TAG ATG CTG TTG NNN NNN NNN -3' sh...
ORGANISM(S): Homo sapiens 
2004-03-03 | E-GEOD-1097 | biostudies-arrayexpress
UnknownHigh BMI Is Associated with Changes in Peritumor Breast Adipose Tissue That Increase the Invasive Activity of Triple-Negative Breast Cancer Cells.
Not available
S-EPMC11476838 | biostudies-literature
UnknownRapid detection of Campylobacter coli, C. jejuni, and Salmonella enterica on poultry carcasses by using PCR-enzyme-linked immunosorbent assay.
Not available
S-EPMC161512 | biostudies-literature
MetabolomicsA Prototypic Small Molecule Database for Bronchoalveolar Lavage-Based Metabolomics
The analysis of bronchoalveolar lavage fluid (BALF) using mass spectrometry-based metabolomics can provide insight into lung diseases, such as asthma. However, the important step of compound identification is hindered by the lack of a small molecule database that is specific for BALF. Here we descri...
2018-02-09 | MTBLS591 | MetaboLights
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