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ProteomicsRNA Encoded Peptide Barcodes Enable Efficient in vivo Screening of RNA Delivery Systems
LNPs have been demonstrated to hold great promise for the clinical advancement of RNA therapeutics. Continued exploration of LNPs for application in new disease areas requires identification and optimisation of leads in a high throughput way. Currently available high throughput in vivo screening pla...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD053797 | Pride
Lnp Proteomics Rna In vivo High throughput Barcodes 
ProteomicsAntisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and 6 extracellular vesicles recycling
Next generation modified antisense oligonucleotides (ASOs) are commercially approved new therapeutic modalities, yet poor productive uptake and endosomal entrapment in tumour cells limit their broad application. We compared intracellular traffic of anti KRAS antisense oligonucleotide (AZD4785) in go...
ORGANISM(S): Homo sapiens (Human) 
2021-11-10 | PXD027804 | Pride
Antisense oligonucletides Lc-ms/ms 
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