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TranscriptomicsGene expression of A53T and corrected IPSC driven to DA neurons and exposed to paraquat and maneb
Parkinson disease (PD) is characterized by extensive loss of A9 dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). A strong association has been reported between PD and exposure to mitochondrial toxins such as the environmental pesticides paraquat, maneb, and rotenone. Here, usi...
ORGANISM(S): Homo sapiens 
2013-12-05 | E-GEOD-46798 | biostudies-arrayexpress
TranscriptomicsDigoxin and its derivatives suppress Th17 cell differentiation by antagonizing RORγt activity
CD4+ T helper lymphocytes that express interleukin-17 (Th17 cells) have critical roles in mouse models of autoimmunity, and there is mounting evidence that they also influence inflammatory processes in humans. Genome-wide association studies in humans have linked genes involved in Th17 cell differe...
ORGANISM(S): Mus musculus 
2011-03-28 | E-GEOD-27241 | biostudies-arrayexpress
TranscriptomicsHuman patient tumor-derived organoid characterization from bladder cancer patients that did not respond to chemotherapy
A total of 3 independently derived organoids were compared to patient tumor samples and patient normal samples to determine if the tumor-derived organoids represent the genomic landscape of the tumor from which they were derived.
ORGANISM(S): Homo sapiens 
2023-01-02 | E-MTAB-10353 | biostudies-arrayexpress
UnknownComparison of 2016-17 and Previous Epizootics of Highly Pathogenic Avian Influenza H5 Guangdong Lineage in Europe.
Not available
S-EPMC6256410 | biostudies-literature
ProteomicsActin-nucleation promoting factor N-WASP influences alpha-synuclein condensates and pathology
Abnormal intraneuronal accumulation of soluble and insoluble alpha-synuclein (alpha-Syn) is one of the main pathological hallmarks of synucleinopathies, such as Parkinson’s disease (PD). It has been well- documented that the reversible liquid-liquid phase separation of alpha-Syn can modulate synapti...
ORGANISM(S): Homo Sapiens (human) Caenorhabditis Elegans 
2025-03-22 | PXD050719 | JPOST Repository
TranscriptomicsTranscriptomic-Based Effects Monitoring for Endocrine Active ChemicalsM-bM-^@M-^TAssessing Relative Contribution of Treated Wastewater to Downstream Pollution
Many biomonitoring tools/approaches have been proposed to assess presence of endocrine active chemicals (EACs) and their biological effects in the field. Although these tools have provided valuable information, they are often limited by their specificity for certain groups of EACs and they may not a...
ORGANISM(S): Pimephales promelas 
2014-01-04 | E-GEOD-49098 | biostudies-arrayexpress
UnknownCare-seeking experiences of unattached patients in the Canadian health care system: Qualitative study.
Not available
S-EPMC11280697 | biostudies-literature
UnknownA high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response.
Not available
S-EPMC8959399 | biostudies-literature
GenomicsGlioma GWAS summary statistics
Meta-analysis association statistics from case-control analysis (includes imputed SNPs)
EGAD00010001657 | EGA
GenomicsSummary statistics from genome-wide association study in glioma of 12,488 cases and 18,169 controls.
Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to identify risk loci. We performed a meta-analysis of existing GWAS and two new GWAS, which totaled 12,488 cases and 18,169 controls. We identified five ...
EGAS00001003372 | EGA
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