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TranscriptomicsExpression data from immunophenotypic HSPCs isolated from different stages of human hematopoiesis, in vivo and in vitro
The derivation of functional, transplantable HSCs from an pluripotent stem cells in vitro holds great promise for clinical therapies, but is unachieved. In order to achieve full functionality of HSCs, it is vital to determine the extent to which PSCs can currently be differentiated to the HSC progra...
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-64865 | biostudies-arrayexpress
TranscriptomicsRNA-seq expression data from EB-HSPCs after HOXA7 overexpression
HOXA7 regulates FL-HSPC self-renewal in vitro and in vivo. We profiled EB-HSPCs after HOXA7 overexpression (EB-HOXA7), or with a control vector (EB-CTR), to assess the gene expression programs regulated by HOXA7. CD34+CD38-CD43+CD90+ HSPCs were infected with lentiviral FUGW vector either empty (FUG...
ORGANISM(S): Homo sapiens 
2016-05-16 | E-GEOD-76684 | biostudies-arrayexpress
TranscriptomicsGene expression data from the mesenchymal stem cell line OP9M2 that supported expansion of human hematopoietic stem and progenitor cells in vitro
One of the long-standing goals in the field has been to establish a culture system that would allow maintenance of HSC properties ex vivo. In the absence of such system, the ability to model human hematopoiesis in vitro has been limited, and there has been little progress in the expansion of human H...
ORGANISM(S): Mus musculus 
2013-01-31 | E-GEOD-34973 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of human fetal liver hematopoietic stem and progenitor cells (HSPC) in culture
One of the long-standing goals in the field has been to establish a culture system that would allow maintenance of HSC properties ex vivo. In the absence of such system, the ability to model human hematopoiesis in vitro has been limited, and there has been little progress in the expansion of human H...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-34972 | biostudies-arrayexpress
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