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TranscriptomicsIdentification of genes specific to mouse primordial germ cells through dynamic global gene expression
The molecular mechanisms underlying the commitment of cells to the germ cell lineage and the subsequent formation of germ cells during mammalian development remain poorly understood due to an inability to obtain sufficient amounts of cellular materials to conduct thorough in-vitro analyses. Although...
ORGANISM(S): Mus musculus 
2010-11-16 | E-GEOD-23322 | biostudies-arrayexpress
TranscriptomicsHypoxia induces pluripotency in primordial germ cells by HIF1 alpha stabilization and Oct4 deregulation
To study the mechanisms of pluripotency induction, we compared gene expression in pluripotent embryonic germ cells (EGCs) and unipotent primordial germ cells (PGCs). We found 11 genes ≥1.5-fold overexpressed in EGCs. None of the genes identified were Yamanaka's genes, but instead related to glycoly...
ORGANISM(S): Mus musculus 
2014-09-18 | E-GEOD-61472 | biostudies-arrayexpress
TranscriptomicsGerm cell nuclear factor regulates gametogenesis in developing gonads
Expression of germ cell nuclear factor (GCNF, Nr6a1), an orphan member of the nuclear receptor gene family of transcription factors, during gastrulation and neurulation is critical for normal embryogenesis in mice. Gcnf represses the expression of the POU domain transcription factor Oct4 (Pou5f1) du...
ORGANISM(S): Mus musculus 
2015-05-08 | E-GEOD-57506 | biostudies-arrayexpress
TranscriptomicsTranscriptome of mouse pluripotent embryonic stem cells (mESC) cultured in R2i, 2i, PD and SB conditions
In this study we have analyzed the global gene expression of naïve mouse embryonic stem cells in different culture conditions including R2i (PD0325901+SB431542), 2i (PD0325901+CHIR99021), and also PD0325901+LIF and SB431542+LIF to show the similarities and differences between the conditions in maint...
ORGANISM(S): Mus musculus 
2013-10-21 | E-GEOD-43682 | biostudies-arrayexpress
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