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TranscriptomicsGenome-Wide Specificity of DNA-Binding, Gene Regulation, and Chromatin Remodeling by TALE- and CRISPR/Cas9-Based Transcription Factors
Synthetic DNA-binding proteins have found broad application in gene therapies and as tools for interrogating biology. Engineered proteins based on the CRISPR/Cas9 and TALE systems have been used to alter genomic DNA sequences, control transcription of endogenous genes, and modify epigenetic states. ...
ORGANISM(S): Homo sapiens 
2015-05-27 | E-GEOD-68341 | biostudies-arrayexpress
GenomicsRisk Variants for Exfoliation Syndrome Modulate Antisense Promoter Activity Within the LOXL1 Locus
The goal of this study was to identify functional variants that play a role in exfoliation syndrome (XFS) pathogenesis. We sequenced the entire LOXL1 locus in 50 South African XFS cases and 50 matched controls. The most strongly associated variants in this dataset were found in a ~7kb region spannin...
ORGANISM(S): Homo sapiens 
2015-07-22 | E-GEOD-66877 | biostudies-arrayexpress
GenomicsGenome-Wide Specificity of DNA-Binding, Gene Regulation, and Chromatin Remodeling by TALE- and CRISPR/Cas9-Based Transcription Factors
Synthetic DNA-binding proteins have found broad application in gene therapies and as tools for interrogating biology. Engineered proteins based on the CRISPR/Cas9 and TALE systems have been used to alter genomic DNA sequences, control transcription of endogenous genes, and modify epigenetic states. ...
ORGANISM(S): Homo sapiens 
2015-04-24 | E-GEOD-57085 | biostudies-arrayexpress
GenomicsChromatin accessibility profiling of developing cerebellar granule neurons identifies novel neuronal enhancers and reveals a role for Zic transcription factors in neuronal maturation
To identify chromatin mechanisms of neuronal differentiation, we characterized the relationship between chromatin accessibility and gene expression in cerebellar granule neurons (CGNs) of the developing mouse. We used DNase-seq to globally map accessibility of cis-regulatory elements and RNA-seq to ...
ORGANISM(S): Mus musculus 
2015-02-27 | E-GEOD-60731 | biostudies-arrayexpress
GenomicsDirect GR binding sites potentiate clusters of TF binding across the human genome [6]
The glucocorticoid receptor (GR) binds the human genome at >10,000 sites, but only regulates the expression of hundreds of genes. To determine the functional effect of each site, we measured the glucocorticoid (GC) responsive activity of nearly all GR binding sites (GBSs) captured using chromatin im...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-79429 | biostudies-arrayexpress
GenomicsDirect GR binding sites potentiate clusters of TF binding across the human genome [8]
The glucocorticoid receptor (GR) binds the human genome at >10,000 sites, but only regulates the expression of hundreds of genes. To determine the functional effect of each site, we measured the glucocorticoid (GC) responsive activity of nearly all GR binding sites (GBSs) captured using chromatin im...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-79431 | biostudies-arrayexpress
TranscriptomicsDirect GR binding sites potentiate clusters of TF binding across the human genome [3]
The glucocorticoid receptor (GR) binds the human genome at >10,000 sites, but only regulates the expression of hundreds of genes. To determine the functional effect of each site, we measured the glucocorticoid (GC) responsive activity of nearly all GR binding sites (GBSs) captured using chromatin im...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-79426 | biostudies-arrayexpress
TranscriptomicsDirect GR binding sites potentiate clusters of TF binding across the human genome [2]
The glucocorticoid receptor (GR) binds the human genome at >10,000 sites, but only regulates the expression of hundreds of genes. To determine the functional effect of each site, we measured the glucocorticoid (GC) responsive activity of nearly all GR binding sites (GBSs) captured using chromatin im...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-79425 | biostudies-arrayexpress
TranscriptomicsDirect GR binding sites potentiate clusters of TF binding across the human genome [4]
The glucocorticoid receptor (GR) binds the human genome at >10,000 sites, but only regulates the expression of hundreds of genes. To determine the functional effect of each site, we measured the glucocorticoid (GC) responsive activity of nearly all GR binding sites (GBSs) captured using chromatin im...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-79427 | biostudies-arrayexpress
TranscriptomicsDirect GR binding sites potentiate clusters of TF binding across the human genome [1]
The glucocorticoid receptor (GR) binds the human genome at >10,000 sites, but only regulates the expression of hundreds of genes. To determine the functional effect of each site, we measured the glucocorticoid (GC) responsive activity of nearly all GR binding sites (GBSs) captured using chromatin im...
ORGANISM(S): Homo sapiens 
2016-08-25 | E-GEOD-79424 | biostudies-arrayexpress
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