Sort   by:  
 Page size 
TranscriptomicsU937 scramble vs shHDAC2 upon SAHA (Vorinostat; suberoylanilide hydroxamic acid) treatment
Transcriptional profiling of U937 scramble vs shHDAC2 before and after SAHA treatment at 5µM concentration for 6 and 24 hours. Different Experimental Conditions: U937 scramble (U937 trasfected with empty vector) vs shHDAC2 (U937 trasfected with shHDAC2 vector), untreated and treated with SAHA at 5 ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-37529 | biostudies-arrayexpress
TranscriptomicsExpression data from SKOV3 cells treated with SAHA or vehicle control
We performed a microarray experiment to assess SAHA-induced changes in expression of genes of the homologous recombination DNA repair pathway SKOV-3 ovarian cancer cells were treated with 1µM SAHA or vehicle-control (0.01% DMSO) for 6 or 24 hours, harvested and processed for RNA isolation. Data fo...
ORGANISM(S): Homo sapiens 
2014-03-19 | E-GEOD-53603 | biostudies-arrayexpress
TranscriptomicsPrimary human erythroid progenitor cells SAHA treatment samples
Gene expression profiling was performed on primary human erythroid progenitor cells left untreated or treated with 0.5uM SAHA. The worldwide burden of sickle cell disease is enormous, with over 200,000 infants born with the disease each year in Africa alone. Induction of fetal hemoglobin is a valida...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-22367 | biostudies-arrayexpress
TranscriptomicsRNA expression in MDA-MB-231 cells treated for 24h with SAHA, Pargyline, or both [HG-U133A_2]
Abnormal activities of histone lysine demethylases (KDMs) and lysine deacetylases (HDACs) are associated with aberrant gene expression in breast cancer development. However, the precise molecular mechanisms underlying the crosstalk between KDMs and HDACs in chromatin remodeling and regulation of gen...
ORGANISM(S): Homo sapiens 
2015-09-04 | E-GEOD-72688 | biostudies-arrayexpress
TranscriptomicsExamination of gene expression in human breast cancer cells exposed to the HDAC inhibitor SAHA
The identification of proteins that change in response to a drug perturbation can shed light on the molecular mechanisms of the drug and its potential use in therapies. Histone deacetylases (HDACs) are targets for cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is an FDA approved HDAC inhibit...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-60124 | biostudies-arrayexpress
UnknownCrystal structure and Hirshfeld surface analysis of (aqua-κO)(methanol-κO)[N-(2-oxido-benzyl-idene)threoninato-κ3 O,N,O']copper(II).
Not available
S-EPMC7472767 | biostudies-literature
TranscriptomicsCombination of ABT-869 with SAHA on AML with FLT3-ITD
For the microarray experiments, MV4-11 and MOLM-14 cells were treated with DMSO control, ABT-869 3 nM, SAHA 6 M and combination therapy for 24 hours. Cells were then washed in PBS and high-quality total RNA was extracted RNeasy Midi Kit, according to the manufacturer’s instruction (Qiagen, Valencia...
ORGANISM(S): Homo sapiens 
2011-05-31 | E-GEOD-26114 | biostudies-arrayexpress
GenomicsHistone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone 4 (H4) Epigenome (ChIP-Seq)
ChIP-Seq analysis revealed that suberoylanilidehydroxamic acid (SAHA) increases genome-wide H4 acetylation in differentially regulated genes, except for the 500 bp upstream of transcription start sites (TSS). Chromatin immunoprecipitation (ChIP) with massively parallel high throughput sequencing (Se...
ORGANISM(S): Mus musculus 
2013-09-04 | E-GEOD-50551 | biostudies-arrayexpress
UnknownCo₃O₄@CoS Core-Shell Nanosheets on Carbon Cloth for High Performance Supercapacitor Electrodes.
Not available
S-EPMC5553425 | biostudies-literature
UnknownBenign-by-Design SAHA Analogues for Human and Animal Vector-Borne Parasitic Diseases.
Not available
S-EPMC11403742 | biostudies-literature
Sort   by:  
 Page size