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ProteomicsPost-translational modification analysis of VDAC1 in ALS-SOD1 model cells reveals specific asparagine and glutamine deamination
Mitochondria from affected tissues of Amyotrophic Lateral Sclerosis (ALS) patients show morphological and biochemical abnormalities. The impairment of mitochondrial functions causes oxidative damage and accumulation of ROS and represents one of the major features that lead to the selective death of ...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-10 | PXD022598 | Pride
Deamidation  amyotrophic lateral sclerosis  voltage dependent anion channel  post-translational modifications  mitochondria  ros  mass spectrometry analysis  orbitrap fusion tribrid  neurodegeneration  sod1 
ProteomicsSpecific post-translational modifications of VDAC3 in ALS-SOD1 model cells identified by High-Resolution Mass Spectrometry
Damage induced by oxidative stress is a key driver of the selective motor neuron death in amyotrophic lateral sclerosis (ALS). Mitochondria are among the main producers of ROS, but they also suffer particularly from their harmful effects. Voltage-dependent anion-selective channels (VDACs) are the mo...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD036728 | Pride
Deamidation  amyotrophic lateral sclerosis  voltage dependent anion channel  post-translational modifications  mitochondria  ros  mass spectrometry analysis  orbitrap fusion tribrid  neurodegeneration  sod1. 
ProteomicsIntramolecular disulfide bridges in Voltage-Dependent Anion Channel 2 (VDAC2) protein from Rattus norvegicus revealed by high resolution mass spectrometry.
Voltage-Dependent Anion Channel isoforms (VDAC1, VDAC2, VDAC3) are relevant component of the outer mitochondrial membrane and play crucial role in cellular processes, in regulation of metabolism and in survival pathways. Recently, we reported the characterization of the oxidation pattern of cysteine...
ORGANISM(S): Rattus rattus (Black rat) 
2024-06-16 | PXD044041 | Pride
High-resolution mass spectrometry  intramolecular disulfide bridges  rattus voltage-dependent anion selective channel isoform 2 (rvdac2)  cysteine redox state  structural characterization. 
ProteomicsStructural characterization of intra- and intermolecular disulfide bonds in Voltage-Dependent Anion Channel 3 (VDAC3) protein from Rattus norvegicus by high-resolution mass spectrometry
Voltage-Dependent Anion Channels, the most abundant proteins of the mitochondrial outer membrane, are responsible for exchange of ions and metabolites between cytosol and mitochondria. They participate in the control of glycolytic metabolism through interaction with numerous enzymes and play a key r...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-09-08 | PXD064110 | Pride
High-resolution mass spectrometry  intra- and intermolecular disulfide bonds  rattus voltage-dependent anion selective channel isoform 3 (rvdac3)  cysteine redox state  structural characterization 
ProteomicsA High Resolution Mass Spectrometry Study Reveals the Potential of Disulfide Formation in Human Mitochondrial Voltage-Dependent Anion Selective Channel Isoforms (hVDACs)
The voltage-dependent anion-selective channels (VDACs), also known as eukaryotic porins, are pore-forming proteins which allow the passage of ions and small molecules across the outer mitochondrial membrane (OMM). They are involved in complex interactions regulating organelle and cellular metabolism...
ORGANISM(S): Homo sapiens (Human) 
2020-03-09 | PXD017482 | Pride
Cysteine over-oxidation  mitochondria  orbitrap fusion tribrid  hydroxyapatite  mitochondrial intermembrane space  outer mitochondrial membrane  post-translational modification 
ProteomicsCount Dracula Resurrected: Proteomic Analysis of Vlad III the Impaler’s Documents by EVA Technology and Mass Spectrometry
The interest of scientists in analysing items of World Cultural Heritage, has been exponentially increasing since the beginning of the new millennium. These studies have grown considerably in tandem with the development and the use of sophisticated and sensitive technologies such as the high-resolut...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092916 | MassIVE
ProteomicsStandardization of mitochondrial proteomics v2 NP
Comparison of the extraction performances of three different mitochondria enrichment protocols (differential centrifugation, sucrose gradient, a commercial kit based on surfactants) on ten different cell lines. Samples were analysed on several instrumental platforms. Mitochondrial pellets were lysed...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-07-14 | MSV000081329 | MassIVE
ProteomicsStandardization of mitochondrial proteomics
Comparison of the extraction performances of three different mitochondria enrichment protocols (differential centrifugation, sucrose gradient, a commercial kit based on surfactants) on ten different cell lines. Samples were analysed on several instrumental platforms. Mitochondrial pellets were lysed...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-05-30 | MSV000081121 | MassIVE
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