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TranscriptomicsHigh doses of Everolimus induce transcriptomic changes in bronchial epithelial cells from cystic fibrosis patients
BACKGROUND: At the moment, lung transplantation remains the best therapeutic option to ensure a better survival rate of cystic fibrosis (CF) patients, but, unfortunately, immunosuppressive therapies, often employed at high dosages to avoid acute rejection and a rapid pulmonary loss, may induce sever...
ORGANISM(S): Homo sapiens 
2020-08-31 | E-MTAB-8123 | biostudies-arrayexpress
TranscriptomicsLong non-coding RNA profiling in Human Adult Renal Progenitor Cells and human renal proximal tubular cells
Long non-coding RNA (lncRNA) play an important role in several biological processes including some renal diseases. Nevertheless, little is known on lncRNAs that are expressed in healthy kidney and involved in renal cell homeostasis and development and even less is known about lncRNA involved in the ...
ORGANISM(S): Homo sapiens 
2023-01-06 | E-MTAB-11451 | biostudies-arrayexpress
TranscriptomicsThe mTOR inhibition by Rapamycin limits LPS-induced acute kidney injury and ameliorates hallmarks of cellular senescence
Sepsis is a severe and dysregulated inflammatory disease that often precedes the development of acute kidney injury (AKI) with consequent worsening outcome. The main characteristics of sepsis-induced AKI include endothelial cell (EC) dysfunction, infiltration of inflammatory cells, glomerular thromb...
ORGANISM(S): Homo sapiens 
2024-09-16 | E-MTAB-13396 | biostudies-arrayexpress
TranscriptomicsAltered modulation of WNT-β-catenin and PI3K/Akt pathways in IgA nephropathy
To uncover new molecular mechanisms involved in IgAN pathogenesis, we compared the genomic profiles of 12 IgAN patients with 8 healthy subjects, We included addiotional disease controls 3 FSGS(Focal Segmenal glomerulosclerosis) patients and 3 membrano proliferative glomerulonephritis type I (MPGN-I)...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-14795 | biostudies-arrayexpress
TranscriptomicsmiR-1915 and miR-1225-5p Regulate The Expression of CD133, PAX-2 and TLR2 in Adult Renal Progenitor Cells
Adult renal stem/progenitor cells (ARPCs), first identified in the BowmanM-bM-^@M-^Ys capsule, were recently identified also in the tubular compartment and it was demonstrated that renal progenitors from both locations were positive for PAX-2, CD133 and CD24 and exhibited multipotent differentiation...
ORGANISM(S): Homo sapiens 
2013-05-30 | E-GEOD-42391 | biostudies-arrayexpress
TranscriptomicsRole of interferon-alpha in the activation of tubular epithelial cell in lupus nephritis (LN)
Plasmacytoid dendritic cells (pDCs) play a key role in the activation of the autoimmune response in LN. Recently we demonstrated that these cells infiltrate the kidney of patients with LN at tubulointerstitial level. The pDCs are the main producers of IFN-alpha, whose effects on the renal tubule are...
ORGANISM(S): Homo sapiens 
2015-12-15 | E-GEOD-48551 | biostudies-arrayexpress
TranscriptomicsIsolation and characterization of Renal Cancer Stem Cells (RCSCs) obtained from clear cell renal cell carcinoma (cc-RCC)
Purpose: The aim of the present study was to identify and characterize in tissue samples of clear cell-renal cell carcinoma (ccRCC) a population of CD133+/CD24+ cancer cells (RCC-derived cells-RDCs) and to study the differences with their nonneoplastic counterpart, tubular Adult Renal Progenitor Cel...
ORGANISM(S): Homo sapiens 
2015-12-15 | E-GEOD-48550 | biostudies-arrayexpress
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