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TranscriptomicsCharacterization of the human cumulus cell transcriptome during final follicular maturation and ovulation
Purpose: The goal of this study was to identify differentially expressed genes and pathways between the cumulus of compact/unstimulated cumulus-oocyte-complex (COC) and the cumulus of expanded/stimulated COC. Methods: mRNA profiles of Compact/unstimulated cumulus cells (CCs) from germinal vesicle...
ORGANISM(S): Homo sapiens 
2014-06-04 | E-GEOD-50174 | biostudies-arrayexpress
Transcriptomicsm6A mapping in human RNA (untreated)
We developed a novel approach, m6A-seq, for high-resolution mapping of the transcriptome-wide m6A landscape, based on antibody-mediated capture followed by massively parallel sequencing. Identification of m6A modified sequences in HepG2 cells.
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37003 | biostudies-arrayexpress
Transcriptomicsm6A mapping in human RNA (with treatments)
We developed a novel approach, m6A-seq, for high-resolution mapping of the transcriptome-wide m6A landscape, based on antibody-mediated capture followed by massively parallel sequencing. Identification of m6A modified sequences in HepG2 cells. HepG2 cells were incubated with either IFNg (200ng/ml) o...
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37002 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human breast cancer cell lines using five miRNA microarray platforms
Analysis of hybridisation performance and utility in identifying differentially expressed miRNAs of six miRNA microarray platforms using three biological samples in quadruplicate.
ORGANISM(S): Homo sapiens 
2010-02-24 | E-MTAB-96 | biostudies-arrayexpress
GenomicsChIP-seq analysis of Foxa2 binding sites in midbrain dopaminergic progenitors
Embryonic stem (ES) cells were differentiated in culture to midbrain dopaminergic (mDA) progenitors and subjected to ChIP-seq analysis to resolve genome-wide binding sites of forkhead box protein A2 (Foxa2). Foxa2 was found to directly regulate multiple lineage pathways to specify midbrain dopaminer...
ORGANISM(S): Mus musculus 
2012-07-01 | E-MTAB-1137 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of WT and ime4-/- mutant yeast cells, under vegetative and meiosis-inducing conditions
Inactivation of the yeast IME4 gene, the yeast homologue of METTL3, was shown to result in the loss of m6A in mRNA of mutant cells grown in sporulation medium. We attempted to characterize the effects of ime4 deletion on gene expression under vegetative and meiosis-inducing conditions. The results ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-24 | E-GEOD-36958 | biostudies-arrayexpress
TranscriptomicsMETTL3 KD in HepG2 cells
To gain insight into possible processes that require m6A for their function, METTL3 was knocked down (KD) in HepG2 cells by siRNA transfections Differential expression analysis of METTL3 KD versus mock-transfected HepG2 cells, in 2 biological replicates
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37001 | biostudies-arrayexpress
Transcriptomicsm6A mapping in mouse RNA (mouse liver and human brain)
We developed a novel approach, m6A-seq, for high-resolution mapping of the transcriptome-wide m6A landscape, based on antibody-mediated capture followed by massively parallel sequencing Identification of m6A modified sequences in mouse liver and human brain
ORGANISM(S): Homo sapiens 
2012-04-25 | E-GEOD-37004 | biostudies-arrayexpress
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