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MetabolomicsGut Microbial and Metabolic Responses to Salmonella enterica Serovar Typhimurium and Candida albicans

The gut microbiota is increasingly recognized for playing a critical role in human health and disease, especially in conferring resistance to both virulent pathogens such as Salmonella, which infects 1.2 million people in the United States every year [1], and opportunistic pathogens like Candida,...

2019-09-20 | MTBLS753 | MetaboLights
MetabolomicsCo-exposure to Polyethylene Fiber and Salmonella enterica Typhimurium Alters Microbiome and Metabolome of in vitro Chicken Cecal Mesocosms
Humans and animals encounter a summation of exposures during their lifetime (the exposome). In recent years, the scope of the exposome has begun to include microplastics. Microplastics (MPs) have increasingly been found in locations where there could be an interaction with Salmonella enterica Typhim...
2024-07-08 | MTBLS9001 | MetaboLights
MetabolomicsHolistic Characterization of a Salmonella Typhimurium Infection Model Using Integrated Molecular Imaging

A more complete and holistic view on host–microbe interactions is needed to understand the physiological and cellular barriers that affect the efficacy of drug treatments and allow the discovery and development of new therapeutics. Here, we developed a multimodal imaging approach combining histop...

2022-04-07 | MTBLS2671 | MetaboLights
TranscriptomicsTranscription profiling of Salmonella enterica serovar Typhimurium hha ydgT mutants
transcriptomic analysis of hha ydgT mutants in Salmonella enterica serovar Typhimurium
ORGANISM(S): Salmonella typhimurium 
2008-01-01 | E-MEXP-1303 | biostudies-arrayexpress
MetabolomicsSalmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S. Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on...

2024-05-22 | MTBLS2347 | MetaboLights
TranscriptomicsTranscription profiling of 61 Salmonella enterica serovar Typhimurium isoltates to identify hotspots in genome variation and distinguish between different isolates from the same geographical region
A collection of 61 Salmonella enterica serovar Typhimurium (S. Typhimurium) of animal and human origin, matched as closely as possible by phage type, antimicrobial resistance pattern and place / time of isolation, and sourced from farms or hospitals in Scotland, were analysed by antimicrobial suscep...
ORGANISM(S): Salmonella enterica serotype Typhimurium 
2007-06-09 | E-SGRP-6 | biostudies-arrayexpress
no omics definedTranscription profiling of wild type, waaG mutant and rfaH mutant Salmonella enterica serovar Enteritidis PT4 and serovar Typhimurium to investigate live-attenuated vacine candidates
Effect of mutation of rfaH on gene expression in Salmonella enterica serovar Enteritidis PT4 and Salmonella enterica serovar Typhimurium 4/74
ORGANISM(S): Salmonella enterica 
2006-11-13 | E-MEXP-844 | biostudies-arrayexpress
TranscriptomicsSalmonella enterica serovar Typhimurium 4/74 transcriptomics using strand-specific RNA-seq
Bacterial transcription networks typically consist of hundreds of transcription factors and thousands of promoters. However, current attempts to map bacterial promoters have failed to report the true complexity of bacterial transcription. The differential RNA-seq (dRNA-seq) approaches only identifie...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2013-12-18 | E-GEOD-49829 | biostudies-arrayexpress
GenomicsNext-Generation Sequencing of sgRNA spacer sequences from a CRISPRi library screen of the Salmonella enterica serovar Typhimurium 14028s genome in response to repeated monoclonal IgA treatment
For this study, we implemented the anti-lipopolysaccharide monoclonal IgA Sal4 in a genome-wide CRISPR interference (CRISPRi) screen to identify genes that modulate the extent of agglutination of Salmonella enterica serovar Typhimurium (STm) in response to antibody exposure. We leveraged our recentl...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2025-02-16 | E-MTAB-14834 | biostudies-arrayexpress
TranscriptomicsExpression profiling by array of Salmonella enterica serovar Typhimurium (SL1344) qseC mutant x wild type
“Stress, survival and virulence: the multi-faceted host/microbial interactions.” Bacteria employ epinephrine and norepinephrine, which converge to distinct bacterial crucial processes, like survival and pathogenicity. A novel stress periplasmic membrane protein belonging to previously described BOF...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2012-05-31 | E-GEOD-38353 | biostudies-arrayexpress
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