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TranscriptomicsDnmt3a haploinsufficiency transforms Flt3-ITD myeloproliferative disease into a rapid, spontaneous, and fully-penetrant acute myeloid leukemia (Single Cell RNA-Seq)
Cytogenetically normal acute myeloid leukemia (CN-AML) represents nearly 50% of human acute myeloid leukemia (AML) cases with a 5-year overall survival of approximately 30%. In CN-AML with poorer prognosis, mutations in the de novo DNA methyltransferase (DNMT3A) and the FMS-like tyrosine kinase 3 (F...
ORGANISM(S): Mus musculus 
2016-03-27 | E-GEOD-77847 | biostudies-arrayexpress
TranscriptomicsDnmt3a haploinsufficiency transforms Flt3-ITD myeloproliferative disease into a rapid, spontaneous, and fully-penetrant acute myeloid leukemia (Bulk RNA-Seq)
Cytogenetically normal acute myeloid leukemia (CN-AML) represents nearly 50% of human acute myeloid leukemia (AML) cases with a 5-year overall survival of approximately 30%. In CN-AML with poorer prognosis, mutations in the de novo DNA methyltransferase (DNMT3A) and the FMS-like tyrosine kinase 3 (F...
ORGANISM(S): Mus musculus 
2016-03-27 | E-GEOD-77846 | biostudies-arrayexpress
TranscriptomicsCardiac precursor differentiation from hESCs by lentiviral promoter drug selection
Several of the essential core transcriptional control elements in human embryonic stem cells (ESCs) have been identified, but the production and function of alternative isoforms in self-renewal, pluripotency and tissue lineage specification remain largely unknown. We have modified the H9 ESC line to...
ORGANISM(S): Homo sapiens 
2008-10-24 | E-GEOD-13297 | biostudies-arrayexpress
TranscriptomicsIntragraft anti-viral-specific gene expression as a distinctive transcriptional signature for polyomavirus-associated nephropathy
Polyoma virus nephropathy (PVAN) is a common cause of kidney allograft dysfunction and loss. Microscopic descriptions of PVAN are very similar to T-cell mediated rejection (TCMR) and have unclear underlying molecular mechanisms. To identify PVAN-specific gene expression, we analyzed 162 kidney biops...
ORGANISM(S): Homo sapiens 
2016-09-30 | E-GEOD-72925 | biostudies-arrayexpress
UnknownIdentification of non-Helicobacter pylori spiral organisms in gastric samples from humans, dogs, and cats.
Not available
S-EPMC1153784 | biostudies-literature
TranscriptomicsDnmt3a haploinsufficiency transforms Flt3-ITD myeloproliferative disease into a rapid, spontaneous, and fully-penetrant acute myeloid leukemia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-03-27 | E-GEOD-77849 | biostudies-arrayexpress
UnknownSystems-level perspective of sudden infant death syndrome.
Not available
S-EPMC4193964 | biostudies-literature
TranscriptomicsWhole-transcriptome high-throughput RNA sequencing of blood leukocytes from Parkinson's disease human patients pre- and post-deep brain stimulation
The given data set is the first deep sequencing transcriptome-wide data set of human Parkinson's disease (PD) patients RNA. The data set was produced from blood leukocytes of PD patients, from the same patients following deep brain stimulation (DBS), and from matched healthy control volunteers. Post...
ORGANISM(S): Homo sapiens 
2014-07-16 | E-GEOD-42608 | biostudies-arrayexpress
UnknownQuantifying tumor specificity using Bayesian probabilistic modeling for drug target discovery and prioritization.
Not available
S-EPMC10028977 | biostudies-literature
UnknownpyInfinityFlow: optimized imputation and analysis of high-dimensional flow cytometry data for millions of cells.
Not available
S-EPMC10166583 | biostudies-literature
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