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MetabolomicsComparative Metabolomic Sampling of Upper and Lower Airways by Four Different Methods to Identify Biochemicals That May Support Bacterial Growth
Bacteria need nutrients from the host environment to survive, yet we know little about which biochemicals are present in the airways (the metabolome), which of these biochemicals are essential for bacterial growth and how they change with airway disease. The aims of this pilot study were to develop ...
2019-06-13 | MTBLS179 | MetaboLights
ProteomicsDiscovering the novel role of the S-adenosyl methionine synthetase SAMS-1 in mediating mitochondrial homeostasis during aging
Current worldwide demographics came to the point of the prevalence of people of middle age when the majority of age-related disease start to occur. The existing strategies (dietary and pharmacological interventions) are mostly tested or include treatment starting from young age to promote healthy ag...
ORGANISM(S): Caenorhabditis elegans 
2026-02-23 | PXD024180 | Pride
Mitochondria Aging 
TranscriptomicsTranscription profiling of rat efferent ductules treated with the anti-estrogen fulvestrant ICI 182780
The aim of this study was to analyze the effects of the antiestrogen fulvestrant (ICI 182,780) on gene expression of the rat efferent ductules. Thirty day-old rats were treated once a week for 2 months with vehicle (control group) or ICI 182,780 (AstraZeneca; 10 m g/rat, s.c.). Total RNA of the effe...
ORGANISM(S): Rattus norvegicus 
2008-06-09 | E-MEXP-1497 | biostudies-arrayexpress
ProteomicsSzewczyk_InhibitionOfPRMT7_P36_2020
This dataset consists of 16 raw MS files, acquired on Orbitrap Fusion Lumos Tribrid mass spectrometer operated in Data Dependent Acquisition (DDA) mode for the 8 input files and DDA with simultaneous parallel reaction monitoring (targeted masses; 599.33, 604.33, 608.23, 606.33, 407.89, 403.22, 651.3...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-01-08 | MSV000084773 | MassIVE
ModelsZakhartsev2022 - Constraint-based model of metabolism of Atlantic salmon (Salmo salar)
SALARECON links the Atlantic salmon genome to metabolic fluxes and growth, focusing on energy, amino acid, and nucleotide metabolism.
2023-01-11 | MODEL2207070001 | BioModels
TranscriptomicsInhibitors that block initiation of wall teichoic acid biosynthesis sensitize methicillin-resistant Staphylococcus aureus to beta-lactams
Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase with reduced susceptibility to beta-lactam antibiotics. Here, we show that preventing the expression of wall teichoic acids...
ORGANISM(S): Staphylococcus aureus 
2010-10-19 | E-GEOD-24439 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neural stem and neuroblastoma cells
Both in situ synthesized long oligo arrays from Agilent Technologies and short oligo arrays from Affymetrix were used to meausre differential gene expression in RNA samples generated from (1) human neural stem cells treated with vehicle (EtOH, 0.01%) and tert-butylhydroquinone (tBHQ, 20µM) for 24h,...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-768 | biostudies-arrayexpress
TranscriptomicsSAMHD1 restrains aberrant nucleotide insertions at repair junctions generated by DNA end joining
Aberrant end joining of DNA double strand breaks leads to chromosomal rearrangements and to insertion of nuclear or mitochondrial DNA into breakpoints, which is commonly observed in cancer cells and constitutes a major threat to genome integrity. However, the mechanisms that are causative for these ...
ORGANISM(S): Homo sapiens 
2021-01-20 | E-MTAB-8382 | biostudies-arrayexpress
TranscriptomicsExpression data from esd7-1 mutant vs wt (Ler)
We have characterized a mutation affecting the Arabidopsis EARLY IN SHORT DAYS 7 (ESD7) gene encoding the catalytic subunit of the DNA polymerase epsilon (e), AtPOL2A. esd7-1 mutations causes early flowering independently of photoperiod, shortened inflorescence internodes and altered leaf and root d...
ORGANISM(S): Arabidopsis thaliana 
2010-10-14 | E-GEOD-18603 | biostudies-arrayexpress
GenomicsWhole-genome nucleosome mapping in meiotic diploid S. cerevisiae
We determined nucleosome positions throughout the genome in diploid S. cerevisiae undergoing early stages of synchronous meiosis. This study sought to assess if systematic reorganization of nucleosomes occurs during meiotic prophase at or near sites of DNA double strand break formation. Six samples ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-03-07 | E-GEOD-26452 | biostudies-arrayexpress
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