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TranscriptomicsNova1 is a master regulator of alternative splicing in pancreatic beta cells
Alternative splicing (AS) is a fundamental mechanism for the regulation of gene expression. It affects more than 90% of human genes but its role in the regulation of pancreatic beta cells, the producers of insulin, remains unknown. Our recently published data indicated that the M-bM-^@M-^\neuron spe...
ORGANISM(S): Rattus norvegicus 
2014-10-01 | E-GEOD-59633 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate
Pancreatic beta-cell dysfunction and death are central in the pathogenesis of type 2 diabetes. Saturated fatty acids cause beta-cell failure and contribute to diabetes development in genetically predisposed individuals. Here we used RNA-sequencing to map transcripts expressed in five palmitate-treat...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-53949 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing and small RNA-sequencing of 465 lymphoblastoid cell lines from the 1000 Genomes
This RNA sequencing data set of 465 human lymphoblastoid cell line samples from the CEU, FIN, GBR, TSI and YRI populations from the 1000 Genomes sample collection was created by the Geuvadis consortium (www.geuvadis.org, http://www.geuvadis.org/web/geuvadis/our-rnaseq-project). The data is under emb...
ORGANISM(S): Homo sapiens 
2012-12-06 | E-GEUV-3 | biostudies-arrayexpress
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