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TranscriptomicsTranscription profiling of adipose tissue from wild type and ob/ob mice showing symptoms of obesity and diabetes
The expression of adipogenic genes is decreased in obesity and diabetes mellitus ; Samuel T. Nadler*, Jonathan P. Stoehr*, Kathryn L. Schueler*, Gene Tanimoto, Brian S. Yandell, and Alan D. Attie*,§ ; Departments of * Biochemistry, and Statistics and Horticulture, University of Wisconsin, Madison,...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2952 | biostudies-arrayexpress
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
GenomicsNational Cancer Institute Cancer Genome Characterization Initiative (CGCI)

The Office of Cancer Genomics at the National Cancer Institute is sponsoring a series of studies as part of the Cancer Genome Characterization Initiative (CGCI) to assess novel emerging sequencing technologies in cancer. The CGCI program includes comprehensive characterization of the genetic a...

phs000235.v3.p1 | EGA
UnknownThe hierarchical structure of error-related negativities elicited from affective and social stimuli and their relations to personality traits.
Not available
S-EPMC7808877 | biostudies-literature
GenomicsBRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic development. Here we report that deletion of the DNA damage responsefactor 53BP1 overcomes embryonic lethality in Brca1-nullizygous mice, and rescues HR deficiency, as measured by hypersensitivity to PARP (polyADP...
ORGANISM(S): Mus musculus 
2012-09-30 | E-GEOD-35698 | biostudies-arrayexpress
UnknownAlterations in DNA Damage Response and Repair Genes as Potential Marker of Clinical Benefit From PD-1/PD-L1 Blockade in Advanced Urothelial Cancers.
Not available
S-EPMC6366295 | biostudies-literature
TranscriptomicsAnalysis of the group A Streptococcus CcpA Transcriptome
This study evaluate how catabolite control protein A (CcpA) inactivation affected gene transcript levels in the group A Streptococcus serotype M1 strain MGAS5005 during growth in standard laboratory medium. Keywords: transcriptome analysis 4 replicates of strain MGAS5005 and delta_cppA were grown in...
ORGANISM(S): Streptococcus sp. 'group A' 
2010-05-26 | E-GEOD-10156 | biostudies-arrayexpress
UnknownGenetic Determinants of Cisplatin Resistance in Patients With Advanced Germ Cell Tumors.
Not available
S-EPMC5477828 | biostudies-literature
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
GenomicsEpi4K: Gene Discovery in 4,000 Epilepsy Genomes

The Epi4K project began in 2011 as an international, multi-center study that seeks to identify and characterize the genetic bases of complex epilepsies. The Center without Walls Epi4K project includes three cores and four scientific projects, as well as a steering committee comprised of the prima...

phs000653.v1.p1 | EGA
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