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UnknownLUCIA: An open source device for disinfection of N95 masks using UV-C radiation.
Faced with a global pandemic such as the one triggered by the SARS-CoV-2 virus, the medical supply chain has been highly demanded. An item in which this manifested itself more clearly, are the N95 masks, designed to be disposable items, in many cases they have had to be reused. In these emergency co...
S-EPMC7906873 | biostudies-literature
UnknownSynthesis of the Novel N-(2-Hexadecynoyl)-l-Homoserine Lactone and Evaluation of Its Antiquorum Sensing Activity in Chromobacterium violaceum.
Chromobacterium violaceum is commonly found in soil and freshwater within tropical and subtropical regions. Although not a common occurrence, this bacterium has the potential to cause severe diseases in humans and animals, such as liver and lung abscesses and septicemia. Herein we report the ...
S-EPMC11292648 | biostudies-literature
UnknownChemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
The first total synthesis of a C5-curcumin-2-hexadecynoic acid (C5-Curc-2-HDA, 6) conjugate was successfully performed. Through a three-step synthetic route, conjugate 6 was obtained in 13% overall yield and tested for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA)...
S-EPMC4663078 | biostudies-literature
UnknownSynthetic Fatty Acids Prevent Plasmid-Mediated Horizontal Gene Transfer.

Unlabelled

Bacterial conjugation constitutes a major horizontal gene transfer mechanism for the dissemination of antibiotic resistance genes among human pathogens. Antibiotic resistance spread could be halted or diminished by molecules that interfere with the conjugation process. In this wor...
S-EPMC4556808 | biostudies-literature
UnknownPrioritizing cardiovascular disease-associated variants altering NKX2-5 and TBX5 binding through an integrative computational approach.
Cardiovascular diseases (CVDs) are the leading cause of death worldwide and are heavily influenced by genetic factors. Genome-wide association studies have mapped >90% of CVD-associated variants within the noncoding genome, which can alter the function of regulatory proteins, such as transcription f...
S-EPMC10750078 | biostudies-literature
UnknownType IV traffic ATPase TrwD as molecular target to inhibit bacterial conjugation.
Bacterial conjugation is the main mechanism responsible for the dissemination of antibiotic resistance genes. Hence, the search for specific conjugation inhibitors is paramount in the fight against the spread of these genes. In this pursuit, unsaturated fatty acids have been found to specifically in...
S-EPMC4908816 | biostudies-literature
UnknownPlatelets are responsible for the accumulation of β-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis.

Introduction

Platelets contain beta-amyloid precursor protein (APP) as well as Aβ peptide (Aβ) that can be released upon activation. During thrombosis, platelets are concentrated in clots and activated.

Methods

We used in vivo fluorescent analysis and electron microscopy in mice to de...
S-EPMC5205543 | biostudies-literature
UnknownEnhanced Surveillance for Fatal Dengue-Like Acute Febrile Illness in Puerto Rico, 2010-2012.

Background

Dengue is a leading cause of morbidity throughout the tropics; however, accurate population-based estimates of mortality rates are not available.

Methods/principal findings

We established the Enhanced Fatal Acute Febrile Illness Surveillance System (EFASS) to estimate dengu...
S-EPMC5058557 | biostudies-literature
UnknownCardiovascular disease-associated non-coding variants disrupt GATA4-DNA binding and regulatory functions.
Genome-wide association studies have identified thousands of cardiovascular disease (CVD)-associated variants, with over 90% of them being mapped within the non-coding genome. Non-coding variants in regulatory regions of the genome, such as promoters, enhancers, silencers, and insulators, can alter ...
S-EPMC11930153 | biostudies-literature
Unknown[Clinical relationship between reactive arthritis and SARS-CoV-2 infection: A scoping review].

Introduction

Reactive arthritis (ReA) is a monoarthritis or oligoarthritis that mainly affects the extremities, it can be related to bacterial or viral infections. Currently, COVID-19 has been linked to the development of arthropathies due to its inflammatory component.

Objectives

A s...
S-EPMC10235672 | biostudies-literature
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