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TranscriptomicsFunction-based discovery of significant transcriptional temporal patterns in insulin-stimulated muscle cells
Background: Insulin's effect on protein synthesis (translation of transcripts) and post-translational modifications, especially those involving reversible modifications such as phosphorylation of various signaling proteins, are extensively studied. On the other hand, insulin's effect on the transcri...
ORGANISM(S): Rattus norvegicus 
2012-05-02 | E-GEOD-28997 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of pancreatic beta cells during maturation and with function-inactivating mutations
Islet β-cells from newborn mammals need a maturation process to become mature functional beta cells. The detailed molecular mechanisms were not completely understood. This study was designed to reveal the dynamic gene expression changes during pancreatic beta-cell maturation in postnatal mice. We al...
ORGANISM(S): Mus musculus 
2018-04-01 | E-MTAB-6615 | biostudies-arrayexpress
TranscriptomicsCorrelating pancreatic beta cell function with their transcriptional profiles
The stage at which beta cells become functional were first determined with GSIS and Ca++ imaging. Then beta cells at key stages of maturation were purified and their gene expression alterations were determined with RNAseq and exhaustive bioinformatics analyses.
ORGANISM(S): Mus musculus 
2015-01-30 | E-MTAB-2266 | biostudies-arrayexpress
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