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TranscriptomicsThe roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus
We investigated the roles of IRF-3 and IRF-7 in innate antiviral immunity against dengue virus (DENV). Double-deficient Irf-3-/-7-/- mice infected with the DENV2 strain S221 possessed 1,000-150,000 fold higher levels of viral RNA than wild-type and single-deficient mice 24 hours after infection; how...
ORGANISM(S): Mus musculus 
2013-08-15 | E-GEOD-49871 | biostudies-arrayexpress
UnknownN-acetylcysteine during critical neurodevelopmental periods prevents behavioral and neurochemical deficits in the Poly I:C rat model of schizophrenia.
Not available
S-EPMC10774365 | biostudies-literature
TranscriptomicsImprinting RNAseq
Long-term hematopoietic stem cells (HSCs), short-term HSCs and multipotent progenitor cells (MPPs) were isolated from bone marrow of four mouse strains (WT, H19-deletion, Igf1r-deletion, and double-deletion) and expression profiled with RNAseq. The behavior of the transcriptomes, and in particular...
ORGANISM(S): Mus musculus 
2013-08-12 | E-MTAB-1628 | biostudies-arrayexpress
MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
UnknownA multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severity.
Not available
S-EPMC8861187 | biostudies-literature
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