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TranscriptomicsGene expression profile of the human T-ALL cell line JURKAT after TYK2 and STAT1 knockdown
Targeted molecular therapy has yielded remarkable outcomes in certain cancers, but specific therapeutic targets remain elusive for many others. As a result of two independent RNA interference (RNAi) screens, we identified pathway dependence on a member of the JAK tyrosine kinase family, TYK2, and it...
ORGANISM(S): Homo sapiens 
2013-03-18 | E-GEOD-44652 | biostudies-arrayexpress
TranscriptomicsGene expression profile of mouse breast cancer V720 cells treated with vehicle or PD 0332991
D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains which allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D associated...
ORGANISM(S): Mus musculus 
2012-10-16 | E-GEOD-40513 | biostudies-arrayexpress
GenomicsATAC-seq analysis for T-ALL cell lines
ATAC-seq analysis for T-ALL cell lines
PRJNA961803 | ENA
TranscriptomicsTAL1 regulated miRNAs
miRNA profiling of Jurkat T-ALL cells after knockdown with two control shRNAs and two shRNAs targeting TAL1 to identify miRNAs that are regulated by TAL1 miRNA profiling using Exiqon arrays 48hrs after transduction of Jurkat cells with two control shRNAs (pLKO1-GFP and pLKO1-LUCIFERASE) vs two shRNA...
ORGANISM(S): Homo sapiens 
2013-06-15 | E-GEOD-46957 | biostudies-arrayexpress
GenomicsRNA-seq analysis after PIK75 treatment in T-ALL cells
RNA-seq analysis after PIK75 treatment in T-ALL cells
PRJNA752041 | ENA
TranscriptomicsGene expression profile of human T-ALL cell line KOPTK1 treated with vehicle or PD 0332991
D-cyclins represent components of cell cycle machinery. To test the efficacy of targeting D-cyclins in cancer treatment, we engineered mouse strains which allow acute and global ablation of individual D-cyclins in a living animal. Ubiquitous shutdown of cyclin D1 or inhibition of cyclin D associated...
ORGANISM(S): Homo sapiens 
2012-10-16 | E-GEOD-40512 | biostudies-arrayexpress
GenomicsISO-seq analysis of MYB isoforms in T-ALL cell lines and patient-derived xenografts
ISO-seq analysis of MYB isoforms in T-ALL cell lines and patient-derived xenografts
PRJNA1111367 | ENA
GenomicsATAC-seq analysis for Jurkat nd RPMI-8402 T-ALL cells
ATAC-seq analysis for Jurkat nd RPMI-8402 T-ALL cells
PRJNA970300 | ENA
GenomicsH3K27ac Hi-ChIP analysis in Jurkat and RPMI-8402 T-ALL cells
H3K27ac Hi-ChIP analysis in Jurkat and RPMI-8402 T-ALL cells
PRJNA970302 | ENA
GenomicsNatural killer/T-cell lymphoma (NKTL) enhancer and expression analysis for their pathogenicity
Natural killer/T-cell lymphoma (NKTL) enhancer and expression analysis for their pathogenicity
PRJNA788938 | ENA
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