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UnknownATG16L1 and NOD2 polymorphisms enhance phagocytosis in monocytes of Crohn's disease patients.
Not available
S-EPMC3949275 | biostudies-literature
TranscriptomicsKupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity.
Kupffer cells have been implicated in the pathogenesis of various liver diseases. However, their involvement in metabolic disorders of the liver, including fatty liver disease, remains unclear. The present study sought to determine the impact of Kupffer cells on hepatic triglyceride storage and to e...
ORGANISM(S): Mus musculus 
2011-10-17 | E-GEOD-33044 | biostudies-arrayexpress
TranscriptomicsPPARγ activation promotes infiltration of alternatively activated macrophages into adipose tissue.
Background: Obesity is associated with infiltration of macrophages into adipose tissue. Adipose macrophages may contribute to an elevated inflammatory status by secreting a variety of pro-inflammatory mediators, including TNFalpha and IL-6. Recent data suggest that during diet-induced obesity the ph...
ORGANISM(S): Mus musculus 
2008-04-29 | E-GEOD-11295 | biostudies-arrayexpress
TranscriptomicsAdipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57Bl/6 mice
Objective: Nonalcoholic fatty liver disease (NAFLD) is linked to obesity and diabetes, suggesting an important role of adipose tissue in the pathogenesis of NAFLD. Here we aim to investigate the interaction between adipose tissue and liver in NAFLD, and identify potential early plasma markers that p...
ORGANISM(S): Mus musculus 
2010-09-09 | E-GEOD-24031 | biostudies-arrayexpress
TranscriptomicsBTG1 modulates ATF4 function in response to cellular stress: implications for tumor cell survival
Analysis of the effect of glutamine starvation in mouse embryonic fibroblasts (MEFs) with and without Btg1 at gene expression level. The hypothesis tested in the present study was that loss of Btg1 affect the expression of stress-response genes. Results provide important information of the different...
ORGANISM(S): Mus musculus 
2014-11-26 | E-GEOD-63642 | biostudies-arrayexpress
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