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TranscriptomicsThe effect of PPARa siRNA on endothelial cells treated with fenofibrate
Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha, but there are reports that fenofibrate affects endothelial cells in PPARa-independent manner. In order to identify PPARa-dependently and PPARa-independently regulated transcripts we ge...
ORGANISM(S): Homo sapiens 
2009-08-24 | E-GEOD-15482 | biostudies-arrayexpress
TranscriptomicsThe effect of fenofibrate on endothelial cells
Fenofibrate is a synthetic ligand for the nuclear receptor peroxisome proliferator-activated receptor (PPAR) alpha, but there are reports that fenofibrate affects endothelial cells in PPARa-independent manner. In order to identify PPARa-dependently and PPARa-independently regulated transcripts we ge...
ORGANISM(S): Homo sapiens 
2010-05-06 | E-GEOD-15483 | biostudies-arrayexpress
TranscriptomicsGenome-wide mapping of FOXM1 binding reveals co-binding with oestrogen receptor alpha in breast cancer cells (expression)
The forkhead transcription factor FOXM1 is a key regulator of the cell cycle and is overexpressed in cancer. Increased levels of FOXM1 are associated with both poor prognosis and oestrogen receptor (ERalpha) status in primary breast cancer. In this study, we map FOXM1 binding genome wide in both ERa...
ORGANISM(S): Homo sapiens 
2013-01-07 | E-GEOD-40766 | biostudies-arrayexpress
GenomicsGenome-wide mapping of FOXM1 binding reveals co-binding with oestrogen receptor alpha in breast cancer cells (ChIP-seq)
The forkhead transcription factor FOXM1 is a key regulator of the cell cycle and is overexpressed in cancer. Increased levels of FOXM1 are associated with both poor prognosis and oestrogen receptor (ERalpha) status in primary breast cancer. In this study, we map FOXM1 binding genome wide in both ERa...
ORGANISM(S): Homo sapiens 
2013-01-07 | E-GEOD-40762 | biostudies-arrayexpress
TranscriptomicsThe effect of TNFa on endothelial cells
To understand the transcripts induced by TNFa and how these may interact in inflammatory networks, the transcriptome of HUCECs stimulated with TNFa was examined in 3 different pools each cosisting of 10 different HUVEC isolates. In the study present here, HUVEC isolates from 3 pools of 10 different ...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-27870 | biostudies-arrayexpress
GenomicSporadic Autism Exomes Reveal a Highly Interconnected Protein Network of De Novo Mutations

It is well established that autism spectrum disorders (ASD) have a strong genetic component; however, for at least 70% of cases, the underlying genetic cause is unknown. Under the hypothesis that de novo mutations underlie a substantial fraction of the risk for developing ASD in families with no ...

phs000482 | dbGaP
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