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TranscriptomicsTranscriptomic analysis of the distal colon of wild type C57BL/6N mice and mice harboring a mutation (S839I) in Gucy2c
A novel mouse harbouring a mutation in receptor guanylyl cyclase C (Gucy2c) that is equivalent to that seen in patients with Familial GUCY2C syndrome was established. Since patients are susceptible to colitis-like disease and IBD, RNAseq was performed on the distal colon in these mice to identify gl...
ORGANISM(S): Mus musculus 
2021-09-13 | E-MTAB-9148 | biostudies-arrayexpress
GenomicsGenomic mapping of cAMP receptor protein binding in relation to transcriptional start sites in Mycobacterium tuberculosis
In this study we have used ChIPseq analysis to perform comprehensive mapping of the binding profile of the cAMP receptor protein (CRPMt) of M. tuberculosis combined with RNAseq studies to further investigate the transcriptional response following crp gene deletion and under alternative growth condi...
ORGANISM(S): Mycobacterium tuberculosis 
2014-06-24 | E-MTAB-2390 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of T84 colorectal carcinoma cells treated with receptor guanylyl cyclace C agonist (stable toxin)
Receptor guanylyl cyclase C (GC-C) is expressed in the intestinal epithelia and plays a key role in intestinal physiology. Activation of GC-C by its ligands has been shown to regulate proliferation and differentiation of enterocytes along the crypt-villus axis. This study aims to identify genes regu...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-45531 | biostudies-arrayexpress
TranscriptomicsRadiation-induced gene translation profiles reveal tumor type and cancer specific components
The goal of this study was to compare the radiation-induced gene translation profiles generated from human tumor cell lines that are treated with radiation. Keywords: stimulus or stress design A panel of cell lines included 5 gliomas, 4 pancreatic carcinomas, 3 breast carcinomas and 2 non-small cell...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-10547 | biostudies-arrayexpress
TranscriptomicsFluvastatin-induced differential global gene expression in human malignant MCF-7 breast cancer cells
The current study analyzed the altered expression profiles of genes that are responsible for fluvastatin-induced breast cancer cell death in MCF-7 cells (ER+ve luminal breast cancer cells). Some of these altered gene expressions were further inter connceted to various pathways which may eventually b...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-59006 | biostudies-arrayexpress
TranscriptomicsGenetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility.
This study investigates three radiation exposure scenarios in BALB/c and C57BL/6 mice: (1) low dose (LD) group -- four weekly doses of 7.5 cGy, (2) high dose (HD) group -- four weekly doses of 1.8 Gy, (3) unexposed group -- four weekly sham exposures. We then used comparative expression profiles of ...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-40066 | biostudies-arrayexpress
TranscriptomicsA newly identified spliced isoform of metadherin differently regulates the global transcriptomic profile in MCF-7 breast cancer cells
The current study analyzed the metadherin (MTDH)-mediated altered gene expression profiles in ER positive MCF-7 cells. Some of these altered gene expressions were further inter connected to various pathways which may eventually be recognized as drug targets or biomarkers in those breast cancers wher...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-59055 | biostudies-arrayexpress
TranscriptomicsFluvastatin-induced differential global gene expression in human metastatic MDA-MB-231 breast cancer cells
The current study analyzed the altered expression profiles of genes that are responsible for fluvastatin-induced breast cancer cell death in MDA-MB-231 cells (ER-ve basal breast cancer cells). Some of these altered gene expressions were further inter connceted to various pathways which may eventuall...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-59007 | biostudies-arrayexpress
TranscriptomicsA newly identified spliced isoform of metadherin differently regulates the global transcriptomic profile in MDA-MB-231 breast cancer cells
The current study analyzed the metadherin (MTDH)-mediated altered gene expression profiles in ER negative MDA-MB-231 cells. Some of these altered gene expressions were further inter connected to various pathways which may eventually be recognized as drug targets or biomarkers in those breast cancers...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-59057 | biostudies-arrayexpress
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
Not available
S-EPMC7995808 | biostudies-literature
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