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We used Affymetrix DNA arrays to investigate the extent to which nuclear HDAC4 accumulation affects neuronal gene expression. Cultured neurons were infected with lentiviruses expressing either wildtype HDAC4 or the constitutuvely nuclear 3SA mutant under the control of neuronal Synapsin promoter. Ne...
ORGANISM(S): Mus musculus 

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

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