Sort   by:  
 Page size 
ProteomicsLongitudinal Deep Multi-Omics Profiling in a CLN3 Minipig Model Reveals Novel Biomarker Signatures for Batten Disease
Development of therapies for CLN3 Batten disease, a rare pediatric lysosomal storage disorder, has been hindered by a lack of etiological insights and translatable biomarkers. Here, we used deep multi-omics to discover new biomarkers using longitudinal serum samples from a porcine model of CLN3 dise...
ORGANISM(S): Sus Scrofa (ncbitaxon:9823) 
2023-07-27 | MSV000092536 | MassIVE
ProteomicsLoss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis
Here we utilized a mouse model of PDAC and human pancreatic cancer cell lines to investigate the role of HIF1alpha in pancreatic cancer. Contrary to the conventional notion that HIF1alpha plays a tumor promoting role in several cancers, our findings indicate a tumor suppressive role of HIF1alpha in ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2019-08-21 | MSV000084223 | MassIVE
Sort   by:  
 Page size