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UnknownMolecular basis for the catalytic specificity of the CTX-M extended-spectrum β-lactamases.
Not available
S-EPMC4303298 | biostudies-literature
UnknownMapping the determinants of catalysis and substrate specificity of the antibiotic resistance enzyme CTX-M β-lactamase.
Not available
S-EPMC9837174 | biostudies-literature
UnknownAn active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M β-lactamase drug-resistance enzymes.
Not available
S-EPMC9640584 | biostudies-literature
UnknownMutagenesis and structural analysis reveal the CTX-M β-lactamase active site is optimized for cephalosporin catalysis and drug resistance.
Not available
S-EPMC10139949 | biostudies-literature
TranscriptomicsRNAi profiling by array of human CD34-derived erythroid progenitors treated with BCL11A siRNAs
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the beta-thalassemia syndromes. Genetic association studies have identified sequence variants in the gene BCL11A that influence HbF levels. Here we examine BCL11A as a pote...
ORGANISM(S): Homo sapiens 
2009-01-13 | E-GEOD-13284 | biostudies-arrayexpress
GenomicsGenome-wide location analysis of WNT (Tcf7l2) and BMP (SMAD1) in human hematopoeitic progenitors co-occupied with lineage specific regulators (GATA1, GATA2)
Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. This represents the human CD34 ChIP-seq portion of this dataset. Human hematopoietic cells were cross-linked with formaldehyde for 20 min. DNA was enriched by chromatin immunoprecipitati...
ORGANISM(S): Homo sapiens 
2011-10-07 | E-GEOD-29194 | biostudies-arrayexpress
UnknownA Quick Route to Multiple Highly Potent SARS-CoV-2 Main Protease Inhibitors*.
Not available
S-EPMC7979488 | biostudies-literature
UnknownA systematic exploration of boceprevir-based main protease inhibitors as SARS-CoV-2 antivirals.
Not available
S-EPMC9264725 | biostudies-literature
UnknownA multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals.
Not available
S-EPMC9235293 | biostudies-literature
UnknownSARS-CoV-2 Main Protease Inhibitors That Leverage Unique Interactions with the Solvent Exposed S3 Site of the Enzyme.
Not available
S-EPMC11181478 | biostudies-literature
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