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TranscriptomicsTranscription profiling of human Th cells induced to polarize to Th1 or Th2 direction in the presence or absence of TGFbeta
Th1 and Th2 cells arise from a common precursor cell in response to triggering through the TCR and cytokine receptors for IL-12 or IL-4. This leads to activation of complex signaling pathways, which are not known in detail. Disturbances in the balance between type 1 and type 2 responses can lead to ...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2770 | biostudies-arrayexpress
TranscriptomicsComparative Genomics of D. ethenogenes 195 and an Unsequenced Dehalococcoides-Containing Enrichment Culture
Tetrachloroethene (PCE) and trichloroethene (TCE) are prevalent groundwater contaminants that can be completely reductively dehalogenated by Dehalococcoides organisms. A Dehalococcoides-containing microbial consortium (ANAS) with the ability to degrade TCE to ethene, an innocuous end-product, was pr...
ORGANISM(S): Dehalobacter restrictus 
2010-06-20 | E-GEOD-9612 | biostudies-arrayexpress
TranscriptomicsThe RNA-binding protein HuR coordinates global changes in gene expression during patterning of early peripheral nerves
Identify mRNA targets of the RNA-binding protein HuR in vivo during Schwann cell development using RIP-chip analysis. IP protocol of endogenous mRNA-transfected HuR complexes was performed as described in Keene et al. (2006). In brief, 500 mg of whole-cell lysate obtained from a pool of NB or P5 sci...
ORGANISM(S): Mus musculus 
2012-01-19 | E-MEXP-3519 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression by sheep and human blood stimulated with the TLR4 agonists lipopolysaccharide and monophosphoryl lipid A [human]
11,431 and 4,992 genes were determined in whole blood of healthy human volunteers and normal sheep, respectively following MPLA and LPS exposure Following the exposure 1,029 human and 175 sheep genes were differentially expressed. Of those 175 sheep genes, 54 had a known human ortolog. The major inf...
ORGANISM(S): Homo sapiens 
2015-12-16 | E-GEOD-72557 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression by sheep and human blood stimulated with the TLR4 agonists lipopolysaccharide and monophosphoryl lipid A [sheep]
11,431 and 4,992 genes were determined in whole blood of healthy human volunteers and normal sheep, respectively following MPLA and LPS exposure Following the exposure 1,029 human and 175 sheep genes were differentially expressed. Of those 175 sheep genes, 54 had a known human ortolog. The major inf...
ORGANISM(S): Ovis aries 
2015-12-16 | E-GEOD-72558 | biostudies-arrayexpress
UnknownEnterovirus D68 infection among hospitalized children with severe acute respiratory illness in El Salvador and Panama, 2012-2013.
Not available
S-EPMC7902261 | biostudies-literature
ProteomicsRapid and culture free identification of Francisella in hare carcasses by high-resolution mass spectrometry
Zoonotic pathogens that can be transmitted via food to humans have a high potential for large-scale emergencies, comprising severe effects on public health, critical infrastructures, and the economy. In this context, the development of laboratory methods to rapidly detect zoonotic bacteria in the fo...
ORGANISM(S): Francisella hispaniensis Francisella tularensis subsp. holarctica Francisella tularensis subsp. mediasiatica Francisella tularensis subsp. tularensis Lepus europaeus Francisella tularensis subsp. novicida Francisella philomiragia 
2020-06-30 | PXD013979 | Pride
Proteome profiling Detection of pathogens High-resolution mass spectrometry Phylogenetic analysis Francisella tularensis 
TranscriptomicsLipopolysaccharide modulates rhinovirus-induced chemokine secretion in monocytes and macrophages.
Rhinovirus (RV) infection has been shown to exacerbate asthma. Understanding of the underlying mechanisms by which RV infections provoke airway inflammation and remodeling in asthma may offer significant insight into asthma pathogenesis and exacerbations as well as offer opportunities for improved d...
ORGANISM(S): Homo sapiens 
2014-01-31 | E-GEOD-54558 | biostudies-arrayexpress
UnknownTreatment of Cushing Disease With Pituitary-Targeting Seliciclib.
Not available
S-EPMC10210614 | biostudies-literature
TranscriptomicsDetermination of the transcription start sites of heterologous promoters in Actinoplanes sp. SE50/110 by 5'-end specific transcriptome sequencing
The promoter structure influences binding and clearance of RNA polymerase and therefore substantially influences expression of a gene. A promoter usually consists of a -10 and a -35-region, an extended -10-motif and A+T-rich upstream promoter elements. Most of these elements are optional, whereas th...
ORGANISM(S): Actinoplanes sp. SE50/110 
2019-10-26 | E-MTAB-8433 | biostudies-arrayexpress
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