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UnknownContribution of TEX15 genetic variants to the risk of developing severe non-obstructive oligozoospermia.
Background: Severe spermatogenic failure (SPGF) represents one of the most relevant causes of male infertility. This pathological condition can lead to extreme abnormalities in the seminal sperm count, such as severe oligozoospermia (SO) or non-obstructive azoospermia (NOA). Most cases of SPG...
S-EPMC9797780 | biostudies-literature
UnknownCommon Variation in the PIN1 Locus Increases the Genetic Risk to Suffer from Sertoli Cell-Only Syndrome.
We aimed to analyze the role of the common genetic variants located in the PIN1 locus, a relevant prolyl isomerase required to control the proliferation of spermatogonial stem cells and the integrity of the blood-testis barrier, in the genetic risk of developing male infertility due to a seve...
S-EPMC9225465 | biostudies-literature
UnknownResuscitation fluid practices in Brazilian intensive care units: a secondary analysis of Fluid-TRIPS.

Objective

To describe fluid resuscitation practices in Brazilian intensive care units and to compare them with those of other countries participating in the Fluid-TRIPS.

Methods

This was a prospective, international, cross-sectional, observational study in a convenience sample of inte...
S-EPMC8275089 | biostudies-literature
UnknownImmune and spermatogenesis-related loci are involved in the development of extreme patterns of male infertility.
We conducted a genome-wide association study in a large population of infertile men due to unexplained spermatogenic failure (SPGF). More than seven million genetic variants were analysed in 1,274 SPGF cases and 1,951 unaffected controls from two independent European cohorts. Two genomic regions wer...
S-EPMC9649734 | biostudies-literature
UnknownKey Factors Associated With Pulmonary Sequelae in the Follow-Up of Critically Ill COVID-19 Patients.

Introduction

Critical COVID-19 survivors have a high risk of respiratory sequelae. Therefore, we aimed to identify key factors associated with altered lung function and CT scan abnormalities at a follow-up visit in a cohort of critical COVID-19 survivors.

Methods

Multicenter ambispect...
S-EPMC9824938 | biostudies-literature
UnknownInfluence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum Time Course.
Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS)....
S-EPMC6912490 | biostudies-literature
UnknownRemdesivir and survival outcomes in critically ill patients with COVID-19: A multicentre observational cohort study.
Not available
S-EPMC9804970 | biostudies-literature
UnknownMajor candidate variables to guide personalised treatment with steroids in critically ill patients with COVID-19: CIBERESUCICOVID study.

Purpose

Although there is evidence supporting the benefits of corticosteroids in patients affected with severe coronavirus disease 2019 (COVID-19), there is little information related to their potential benefits or harm in some subgroups of patients admitted to the intensive care unit (ICU) ...
S-EPMC9211796 | biostudies-literature
UnknownEffect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study.

Background

The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19.

Methods

We did a prospective coho...
S-EPMC10129133 | biostudies-literature
UnknownMachine-learning analysis identifies "elite" viral controllers with increased survival and homeostatic responses in critical COVID-19.
Not available
S-EPMC12031886 | biostudies-literature
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