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An unbalanced karyotype, a condition known as aneuploidy, has a profound impact on cellular physiology and is a hallmark of cancer. Determining how aneuploidy affects cells is thus critical to understanding tumorigenesis. Here we show that aneuploidy interferes with the degradation of autophagosomes...
ORGANISM(S): Homo sapiens 
RNA-sequencing samples from DMSO or Reversine treated hTERT RPE-1 cells. Reversine treated cells were further divided in those still able to continue to proliferate and those that got arrested. Cells were analyzed to generate panel in Figure 6d and e, and Extended Data Figure 8g and h.
ORGANISM(S): Homo sapiens 
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