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GenomicsGenome-wide CRISPR-Cas9 knockout screen in MCF10A with ATP-competitive inhibition of CDC7 (XL-413)
The coordinated activation of DNA replication origins is important for efficient DNA synthesis and genome stability. S-phase cyclin dependent kinases (CDKs) together with CDC7 kinase, are essential to origin activation by converting the pre-replicative complex into a fully active helicase. To identi...
ORGANISM(S): Homo sapiens 
2026-09-30 | E-MTAB-17434 | biostudies-arrayexpress
GenomicsWhole Genome Sequencing of MCF10A cells
The non-tumourigenic human breast epithelial cell line MCF10A is the cell line most commonly used as a model for normal human breast cells. This dataset provides a reference genome for MCF10A. The whole genome, high-throughput sequencing was performed using the Illumina NovaSeq 6000 PE150 system. Bo...
ORGANISM(S): Homo sapiens 
2023-10-01 | E-MTAB-13191 | biostudies-arrayexpress
UnknownMicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells.
Not available
S-EPMC3740286 | biostudies-literature
UnknownDBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.
Not available
S-EPMC11169917 | biostudies-literature
UnknownDrf1, a novel regulatory subunit for human Cdc7 kinase.
Not available
S-EPMC126049 | biostudies-literature
UnknownPTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors.
Not available
S-EPMC10291475 | biostudies-literature
UnknownCDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage.
Not available
S-EPMC7403700 | biostudies-literature
UnknownDDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach.
Not available
S-EPMC5062981 | biostudies-literature
UnknownRepression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML.
Not available
S-EPMC6202320 | biostudies-literature
UnknownA high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response.
Not available
S-EPMC4047068 | biostudies-literature
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