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MetabolomicsSarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights
MetabolomicsMulti-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights
TranscriptomicsOrganogenic nodule formation from internodes of Humulus lupulus
Transcriptional profiling of hop samples throughout in vitro culture on medium with sucrose and hormones IAA and BAP Study of gene expression involved in stress response during in vitro culture and in organogenic nodule formation Hop (Humulus lupulus L.) is an economically important plant forming ...
ORGANISM(S): Humulus lupulus 
2008-09-01 | E-GEOD-12339 | biostudies-arrayexpress
GenomicsChIP-chip data of Thp1-Flag and Sac3-Flag in wild-type cells, and Rrm3-Flag in sac3M-bM-^HM-^F and thp1M-bM-^HM-^F cells
Transcription is a major obstacle for replication fork progression and a cause of genome instability. Such instability increases in mutants with a suboptimal assembly of the nascent messenger ribonucleo-protein particle (mRNP), as THO/TREX and the NPC-associated THSC/TREX-2 complex. Here we show tha...
ORGANISM(S): Saccharomyces cerevisiae 
2014-10-08 | E-GEOD-56700 | biostudies-arrayexpress
ProteomicsProteomic analysis of S-nitrosation sites in Araucaria angustifolia (Bertol.) Kuntze
In the present study, endogenous cysteine S-nitrosation site and S-nitrosated proteins were identified by iodo-TMT labeling during somatic embryogenesis in Brazilian pine, an endangered native conifer of South America.
ORGANISM(S): Araucaria angustifolia 
2022-08-12 | PXD033177 | Pride
Nitric oxide  nitrosoproteomic analysis  nitrosative/oxidative stress  conifers  embryogenesis 
TranscriptomicsMetabolic switches and adaptations deduced from the proteomes of Streptomyces coelicolor wild type and phoP mutant grown in batch culture
Bacteria in the genus Streptomyces are soil dwelling oligotrophs and important producers of secondary metabolites. Previously we showed that global mRNA expression was subject to a series of metabolic and regulatory switches during the life time of a fermentor batch culture of S. coelicolor M145. He...
ORGANISM(S): Streptomyces coelicolor 
2011-12-31 | E-GEOD-31068 | biostudies-arrayexpress
MetabolomicsRepurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. Although neurotoxic insecticides are the gold standard for insect control, they neg...
2021-10-06 | MTBLS2166 | MetaboLights
TranscriptomicsIdentification of putative H2O2 regulated genes during the establishment of the Sinorhizobi...
The involvement of ROS in the legume – Rhizobium symbiotic interaction has been highlighted (Santos et al., 2001; Rubio et al., 2004). This interaction is characterized by the formation of a new organ on the root, the nodule and by the penetration, in parallel, of the bacteria into the root tissue v...
ORGANISM(S): Medicago truncatula 
2009-12-31 | E-GEOD-15866 | biostudies-arrayexpress
TranscriptomicsMicrobial adaptation to environmental niches can be reproduced by experimental evolution
Experimental evolution is a powerful approach to study how ecological forces shape microbial genotypes and phenotypes, but to date strains were predominantly adapted to conditions specific to laboratory environments. The lactic acid bacterium Lactococcus lactis naturally occurs on plants and in the ...
ORGANISM(S): Lactococcus lactis subsp. lactis 
2010-06-24 | E-GEOD-20373 | biostudies-arrayexpress
UnknownThe Role of Fe, S, P, Ca, and Sr in Porous Skeletal Lesions: A Study on Non-adult Individuals Using pXRF.
Not available
S-EPMC11750918 | biostudies-literature
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