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UnknownDesign and development of highly conserved, HLA-promiscuous T cell multiepitope vaccines against human visceral leishmaniasis.

Introduction

No vaccine is currently licensed against human visceral leishmaniasis (VL), a fatal CD4+ T cell immunosupressive disease against which chemotherapy is reduced to a few toxic drugs. The NH36 nucleoside hydrolase is a DNA metabolism vital enzyme present in all Leishmania sp...
S-EPMC11994619 | biostudies-literature
UnknownTailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.

Background

In the Suppression of Ovarian Function Trial (SOFT) and the Tamoxifen and Exemestane Trial (TEXT), the 5-year rates of recurrence of breast cancer were significantly lower among premenopausal women who received the aromatase inhibitor exemestane plus ovarian suppression than among...
S-EPMC6193457 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
UnknownIntegrated genomic characterization of oesophageal carcinoma.
Oesophageal cancers are prominent worldwide; however, there are few targeted therapies and survival rates for these cancers remain dismal. Here we performed a comprehensive molecular analysis of 164 carcinomas of the oesophagus derived from Western and Eastern populations. Beyond known histopatholog...
S-EPMC5651175 | biostudies-literature
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