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TranscriptomicsOncogenic Functions of the Transcription Factor LSF
Overexpression of LSF in less aggressive hepatocellular carcinoma (HCC) cells resulted in highly aggressive, angiogenic and multi-organ metastatic tumors while inhibition of LSF significantly abrogated growth and metastasis of highly aggressive HCC cells in nude mice. We used microarrays to identify ...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-19815 | biostudies-arrayexpress
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TranscriptomicsAstrocyte elevated gene-1 (AEG-1) and c-Myc cooperate to promote hepatocarcinogenesis
Double transgenic mice with hepatocyte-specific expression of AEG-1 and c-Myc show aggressive HCC compared to single transgenics. Gene expression was analyzed to understand the molecular mechanism by which AEG-1 and c-Myc cooperate to promote hepatocarcinogenesis. Livers were collected from naïve adu...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-61875 | biostudies-arrayexpress
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